Objective
Vascular cell adhesion molecule-1 (VCAM-1) is the one of the adhesion molecules that have pivotal role in helping leukocytes to firm binding on endothelial cells and their transendothelial migration to the arterial intima during inflammation. There are studies that have examined the relation between event rates due to coronary heart disease and levels of soluble VCAM-1 (sVCAM-1) in apparently healthy adults and in patients with stable coronary artery disease. Less is known about prognostic significance of sVCAM-1 in acute coronary syndromes.
Methods
The study group consisted of 70 patients who presented with unstable angina (UA) or non-ST-segment elevation myocardial infarction (NSTEMI) and 18 asymptomatic patients who had angiographically proved coronary artery disease. Blood was drawn at the time of presentation. Concentration of sVCAM-1, troponin T and high-sensitivity C-reactive protein (hs-CRP) were determined. Patients were followed for 6 months for the occurrence of major adverse cardiac events which were cardiac death, nonfatal myocardial infarction and recurrent ischemic chest pain.
Methods
The study group consisted of 70 patients who presented with unstable angina (UA) or non-ST-segment elevation myocardial infarction (NSTEMI) and 18 asymptomatic patients who had angiographically proved coronary artery disease. Blood was drawn at the time of presentation. Concentration of sVCAM-1, troponin T and high-sensitivity C-reactive protein (hs-CRP) were determined. Patients were followed for 6 months for the occurrence of major adverse cardiac events which were cardiac death, nonfatal myocardial infarction and recurrent ischemic chest pain.
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