Objective
Clinical improvement with statin therapy may in part be attributed to the effect of statins on the systemic hemostatic profile. The effects of pravastatin, simvastatin, and lovastatin on these parameters have been shown in many studies,but there have been few studies of atorvastatin in hyperlipidemic patients.Furthermore, the short-term effects of atorvastatin on hemostatic and inflammatory parameters in angiographically proved ischemic patients have not been previously evaluated. Therefore, we prospectively investigated the properties of atorvastatin on these parameters in ischemic patients with hyperlipidemia.
Methods
Thirty-eight patients with stable coronary artery disease were treated with atorvastatin and its effect on hemostatic and inflammatory parameters were assessed after three months.Serum concentrations of total cholesterol, triglycerides, and high-density lipoprotein cholesterol were measured by conventional methods. LDL cholesterol was estimated according to Friedewald’s formula. The plasma levels of plasminogen activator inhibitor (PAI-1), tissue plasminogen activator antigen, von Willebrand factor, prothrombin fragment 1+2, fibrinogen and highly sensitive C-reactive protein were determined.
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