Neovascularization induced by autologous bone marrow cell implantation in peripheral arterial disease




Background


Now it is not known which cell type is best for inducing therapeutic angiogenesis in end-stage critical limb ischemia (CLI). We hypothesized that mononuclear cells mobilized with granulocyte colony stimulating factor (G-CSF) into peripheral blood are as effective as highly selective and purified CD133+ and CD34+ endothelia progenitor cells (EPCs). This would have significant clinical implications with regard to study designs and costs of stem cell treatment regimens.




Methods


Patients with critical ischemia of lower extremity donated peripheral blood stem cells after 5 days of stimulation with G-CSF. Five patients in each group were treated with CD 34, CD 133 or mononuclear cells after G-CSF stimulation. We analyzed expression of cells surface markers CD34, VEGFR-2, CD133, CD31 and CD144.

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Nov 16, 2017 | Posted by in CARDIOLOGY | Comments Off on Neovascularization induced by autologous bone marrow cell implantation in peripheral arterial disease

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