Although a number of publications have described the natural history of patients with aortic stenosis (AS), the definition of “natural history” varies widely. Those describing a large number of patients with AS without operative therapy with necropsy findings are rare. Two hundred sixty patients >15 years of age with AS were studied at necropsy over a 50-year period by the same investigator. Of the 260 patients, the valve in 37 (14%) was congenitally unicuspid, in 123 (47%), congenitally bicuspid, and in 100 (38%), tricuspid. Aortic valve structure varied with age of death (in years; unicuspid 52 ± 17, bicuspid 63 ± 12, and tricuspid 70 ± 14 years); gender (men/women: unicuspid 95%/5%, bicuspid 78%/22%, and tricuspid 63%/37%), and frequency of calcium in the mitral valve annulus and epicardial coronary arteries. The patients with cardiac-related symptoms compared with those without were more likely to have a congenitally malformed valve (unicuspid 17% vs 12%; bicuspid 51% vs 29%; tricuspid 31% vs 60%; unadjusted p = 0.013), to die from cardiac disease (86% vs 54%; unadjusted p = 0.001), and to have larger hearts (mean cardiac weight 606 ± 138 g vs 523 ± 121 g; unadjusted p = 0.009) and a larger quantity of calcium in the aortic valve cusps. In conclusion, the length of survival in adults with AS is related to valve structure, gender, presence of cardiac-related symptoms, cardiac mass, and quantity of calcium in the aortic valve cusps.
During the past 80 years or so, a number of reports describing the natural history of patients with valvular aortic stenosis (AS) have been published. Before 1970, most focused on patients with AS studied at necropsy, and most centered on the cause of the AS. After predictably successful aortic valve replacement became a reality in the early 1960s, more reports appeared on the natural history of AS, but “natural history” meant something different in most studies. In some studies, it meant what happened when patients were followed for a specified period of time. In others, the term focused on the survival duration of symptomatic or asymptomatic patients until either an aortic valve operation was performed or death. A few included only subjects who had cardiac catheterization or echocardiography performed such that the severity of the AS was accurately known. No study in the past 50 years has focused on a large group of adults with AS studied at necropsy in whom an aortic valve operation during life had never been performed. Such is the purpose of this report.
Methods
From January 1956 until July 2012, 260 patients with AS unassociated with mitral stenosis were studied at necropsy either at the National Institutes of Health (Pathology Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland) or at Baylor University Medical Center, Dallas, Texas; they are the subject of this study. All hearts were examined and classified by one of us (WCR). Many hearts had been submitted from other hospitals, particularly those in the Washington, DC, and surrounding areas. To be included in this study, at the time of necropsy, patients had to be >15 years of age, have a nonstenotic mitral valve, and had no operative procedure at any time on any cardiac valve. The aortic valve morphologically had to be clearly stenotic, that is, contain enough calcific deposits such that mobility of the aortic valve cusp or cusps was clearly diminished. The underlying structure of the stenotic aortic valve (i.e., unicuspid, bicuspid, or tricuspid) was determined in all cases by the same observer (WCR). The major epicardial coronary arteries were examined for obstructions, and the left ventricular walls were examined for foci of necrosis and fibrosis. Myocardial necrosis/fibrosis was confirmed by study of histologic sections of these areas. The medical records were sought and received from the hospitals submitting the heart specimens. Most stenotic aortic valves were photographed at either the Pathology Branch, National Heart, Lung, and Blood Institute, or in the Cardiovascular Laboratory at Baylor University Medical Center.
Means, SDs, and percentages were calculated to describe the study cohort (n = 260). Differences in demographic, clinical, and morphologic details were tested with a Wilcoxon (for continuous factors) or a chi-square (for categorical factors) test. Unadjusted p values and 95% confidence intervals (CIs) were also estimated. A Bonferroni correction was used to account for multiplicity. A multivariable logistic regression model was used to assess the adjusted-association between patients having symptoms (heart failure, angina pectoris, and/or syncope) and cause of death (e.g., cardiac or vascular). Covariates included gender, valve structure, heart weight (in grams), degree of coronary narrowing, foci of left ventricular necrosis and/or fibrosis, presence of calcium in the coronary arteries (in ≥1 coronary arteries). Likewise, 2 multivariable logistic regression models were used to assess the adjusted-association between age and (1) congenital valve disease and (2) presence of calcium in the coronary arteries. Covariates included patient having symptoms (heart failure, angina pectoris, and/or syncope), gender, valve structure (for calcium model only), heart weight (in grams), degree of coronary narrowing, foci of left ventricular necrosis and/or fibrosis, and presence of calcium in the coronary arteries (congenital valve model only). Restricted cubic splines were used for all continuous variables, and multiple imputation via predictive mean matching was used to account for missing data regarding the independent variables in this model. The adjusted p values, odds ratios, and 95% CIs were also estimated.
The study protocol was approved by the Institutional Review Board of Baylor University Medical Center.
Results
The findings in the present study are summarized in Tables 1 through 7 . Table 1 displays data according to aortic valve structure, Table 2 according to gender, Table 3 according to symptomatic status, Table 4 according to age group at death, Table 5 according to heart weight, and Table 6 according to degree of coronary narrowing. Table 7 provides findings in the 37 patients who had left-sided cardiac catheterization. Table 8 lists findings in the 29 patients whose stenotic aortic valves are illustrated in Figures 1 through 4 . Figure 5 illustrates the length of survival after onset of symptoms: angina pectoris, heart failure, syncope, and various combinations of these. Figure 6 shows the length of survival after onset of any cardiac symptom: angina pectoris, heart failure, syncope, or any combination of these. Figure 7 displays the relation of age to the probability of having a congenitally malformed aortic valve (unicuspid or bicuspid) and calcium in ≥1 coronary arteries.
| Variable | Unicuspid | Bicuspid | Tricuspid | Unadjusted ∗ p Value |
|---|---|---|---|---|
| n = 37 (14%) | n = 123 (47%) | n = 100 (38%) | ||
| Age in years: range (n = 254) | 16–87 | 23–89 | 36–99 | 0.001 |
| (Mean ± SD) | (52 ± 17) | (63 ± 12) | (70 ± 14) | |
| 95% CI | 47,56 | 60,65 | 67,72 | |
| Men/Women (n = 257) | 35/2 | 93/27 | 63/37 | 0.005 |
| 95%/5% | 78%/22% | 63%/37% | ||
| Symptoms † (n = 260) | 0.013 | |||
| Symptomatic | 30 (81%) | 89 (72%) | 54 (54%) | |
| Asymptomatic | 6 (16%) | 15 (12%) | 31 (31%) | |
| Unknown | 1 (3%) | 19 (16%) | 15 (15%) | |
| Mode of death (n = 260) | 0.511 | |||
| Cardiac | ||||
| Sudden | 6 (16%) | 29 (24%) | 26 (26%) | |
| Non-sudden | 28 (76%) | 66 (54%) | 47 (47%) | |
| Vascular | 1 (3%) | 5 (4%) | 2 (2%) | |
| Noncardiac, nonvascular | 2 (5%) | 20 (16%) | 25 (25%) | |
| Unknown | 0 | 3 (2%) | 0 | |
| Heart weight (g): range (n = 231) | 320–880 | 340–1,050 | 305–960 | 0.127 ‡ |
| (Mean ± SD) | (633 ± 136) | (591 ± 148) | (552 ± 132) | |
| 95% CI | 585,681 | 564,618 | 523,581 | |
| Men | 320–880 | 385–1,050 | 380–960 | |
| (637 ± 137) | (620 ± 147) | (603 ± 115) | ||
| Women | 510 | 340–730 | 305–710 | |
| — | (496 ± 119) | (458 ± 108) | ||
| Number of enlarged hearts § (n = 215 of 231) | 31 of 33 (94%) | 100 of 106 (94%) | 84 of 92 (91%) | 0.689 |
| Narrowing of ≥1 major coronary arteries >75% (n = 96/234) | 6 (17%) | 43 (41%) | 47 (51%) | 0.018 |
| Left ventricular (n = 260) | 0.513 | |||
| Necrosis only | 1 (3%) | 8 (7%) | 6 (6%) | |
| Fibrosis only | 15 (41%) | 44 (36%) | 25 (25%) | |
| Both | 2 (5%) | 7 (6%) | 5 (5%) | |
| Neither | 19 (51%) | 64 (52%) | 64 (64%) | |
| Calcium | ||||
| Aortic valve (n = 251) | 0.404 | |||
| 0 | 1 (3%) | 1 (1%) | 1 (1%) | |
| 1+ | 5 (14%) | 9 (8%) | 7 (7%) | |
| 2+ | 2 (5%) | 15 (13%) | 18 (18%) | |
| 3+ | 10 (27%) | 27 (23%) | 30 (31%) | |
| 4+ | 19 (51%) | 64 (55%) | 42 (43%) | |
| Mitral annulus (n = 89 of 245) | 7 (19%) | 22 (20%) | 60 (61%) | 0.001 |
| Coronary arteries (n = 121 of 232) | 11 (31%) | 43 (41%) | 67 (73%) | 0.001 |
† Symptoms include heart failure, angina pectoris, and syncope, or any combination of the 3.
‡ Unicuspid versus tricuspid p value = 0.051.
| Variable | Men | Women | Unadjusted ∗ p Value |
|---|---|---|---|
| n = 191 (74%) | n = 66 (26%) | ||
| Age in years: range (n = 254) | 16–99 | 32–90 | 0.001 |
| (Mean ± SD) | (61 ± 15) | (70 ± 13) | |
| 95% CI | 59,64 | 66,73 | |
| Aortic valve structure (n = 257) | 0.005 | ||
| Unicuspid | 35 (18%) | 2 (3%) | |
| Bicuspid | 93 (49%) | 27 (41%) | |
| Tricuspid | 63 (33%) | 37 (56%) | |
| Symptoms † (n = 257) | 0.973 | ||
| Symptomatic | 129 (68%) | 44 (67%) | |
| Asymptomatic | 38 (20%) | 14 (21%) | |
| Unknown | 24 (12%) | 8 (12%) | |
| Mode of death (n = 257) | 0.558 | ||
| Cardiac | |||
| Sudden | 45 (24%) | 16 (24%) | |
| Non-sudden | 109 (57%) | 32 (48%) | |
| Vascular | 6 (3%) | 2 (3%) | |
| Noncardiac, nonvascular | 30 (16%) | 16 (24%) | |
| Unknown | 1 (1%) | 0 | |
| Heart weight (g): range (n = 231) | 320–1,050 | 305–730 | 0.001 |
| (Mean ± SD) | (617 ± 135) | (474 ± 112) | |
| 95% CI | 598,636 | 440,509 | |
| Number of enlarged hearts ‡ (n = 215 of 231) | 167 of 175 (95%) | 48 of 56 (86%) | 0.129 |
| Coronary narrowing >75% § (n = 95 of 233) | 74 (43%) | 21 (35%) | 0.292 |
| Left ventricular (n = 257) | 0.829 | ||
| Necrosis only | 11 (6%) | 4 (6%) | |
| Fibrosis only | 69 (36%) | 14 (21%) | |
| Both | 11 (6%) | 2 (3%) | |
| Neither | 100 (52%) | 46 (70%) | |
| Calcium | |||
| Aortic valve (n = 249) | 0.385 | ||
| 0 | 3 (2%) | 0 | |
| 1+ | 17 (9%) | 4 (6%) | |
| 2+ | 27 (15%) | 8 (12%) | |
| 3+ | 51 (28%) | 14 (22%) | |
| 4+ | 86 (47%) | 39 (60%) | |
| Mitral annulus (n = 88 of 243) | 51 (28%) | 37 (59%) | 0.001 |
| Coronary arteries (n = 120 of 231) | 85 (49%) | 35 (61%) | 0.100 |
† Symptoms include heart failure, angina pectoris, and syncope, or any combination of the 3.
‡ Hearts weighing >350 g in women and >400 g in men.
| Variable | Symptomatic | Asymptomatic | Unknown | Unadjusted † p Value |
|---|---|---|---|---|
| n = 173 (67%) | n = 52 (20%) | n = 35 (13%) | ||
| Age in years: range (n = 254) | 16–92 | 23–89 | 37–99 | 0.854 |
| (Mean ± SD) | (64 ± 14) | (64 ± 17) | (62 ± 15) | |
| 95% CI | 62,66 | 60,68 | 57,68 | |
| Men/Women (n = 257) | 129/44 75%/25% | 38/14 73%/27% | 24/8 75%/25% | 0.973 |
| Aortic valve structure (n = 260) | 0.013 | |||
| Unicuspid | 30 (17%) | 6 (12%) | 1 (3%) | |
| Bicuspid | 89 (51%) | 15 (29%) | 19 (54%) | |
| Tricuspid | 54 (31%) | 31 (60%) | 15 (43%) | |
| Mode of death (n = 260) | 0.001 | |||
| Cardiac | ||||
| Sudden | 38 (22%) | 14 (27%) | 9 (26%) | |
| Non-sudden | 111 (64%) | 14 (27%) | 16 (46%) | |
| Vascular | 4 (2%) | 4 (8%) | 0 | |
| Noncardiac, nonvascular | 20 (12%) | 20 (38%) | 7 (20%) | |
| Unknown | 0 | 0 | 3 (9%) | |
| Heart weight (g): range (n = 231) | 320–1,050 | 305–920 | 310–1,000 | 0.009 |
| (Mean ± SD) | (606 ± 138) | (523 ± 121) | (563 ± 173) | |
| 95% CI | 584,628 | 484,561 | 511,608 | |
| Men | 320–1,050 | 340–920 | 420–1,000 | |
| (638 ± 131) | (543 ± 115) | (633 ± 147) | ||
| Women | 370–730 | 305–650 | 310–500 | |
| (499 ± 106) | (465 ± 123) | (381 ± 72) | ||
| Number of enlarged hearts ‡ (n = 215 of 231) | 148 of 152 (97%) | 43 of 50 (86%) | 24 of 29 (83%) | 0.015 |
| Narrowing of ≥1 major coronary arteries >75% (n = 96 of 234) | 67 (41%) | 15 (33%) | 14 (56%) | 0.161 |
| Left ventricular (n = 260) | 0.449 | |||
| Necrosis only | 9 (5%) | 4 (8%) | 2 (6%) | |
| Fibrosis only | 64 (37%) | 9 (17%) | 11 (31%) | |
| Both | 12 (7%) | 0 | 2 (6%) | |
| Neither | 88 (51%) | 39 (75%) | 20 (57%) | |
| Calcium | ||||
| Aortic valve (n = 251) | 0.038 | |||
| 0 | 2 (1%) | 1 (2%) | 0 | |
| 1+ | 10 (6%) | 6 (12%) | 5 (17%) | |
| 2+ | 19 (11%) | 13 (25%) | 3 (10%) | |
| 3+ | 40 (23%) | 15 (29%) | 12 (41%) | |
| 4+ | 100 (58%) | 16 (31%) | 9 (31%) | |
| Mitral annulus (n = 89 of 245) | 59 (35%) | 18 (36%) | 12 (43%) | 0.745 |
| Coronary arteries (n = 121 of 232) | 80 (49%) | 24 (52%) | 17 (71%) | 0.147 |
∗ Symptoms include heart failure, angina pectoris, and syncope, or any combination of the 3.
| Variable | Age Groups (years) | Unadjusted ∗ p Value | ||
|---|---|---|---|---|
| 16–35 | 36–65 | >65 | ||
| n = 11 (4%) | n = 119 (47%) | n = 124 (49%) | ||
| Men/Women (n = 254) | 10/1 91%/9% | 97/22 82%/18% | 81/43 65%/35% | 0.069 |
| Aortic valve structure (n = 254) | 0.001 | |||
| Unicuspid | 9 (82%) | 22 (18%) | 6 (5%) | |
| Bicuspid | 2 (18%) | 64 (54%) | 52 (42%) | |
| Tricuspid | 0 | 33 (28%) | 66 (53%) | |
| Symptoms † (n = 254) | 0.229 | |||
| Symptomatic | 6 (55%) | 83 (70%) | 84 (68%) | |
| Asymptomatic | 5 (45%) | 17 (14%) | 30 (24%) | |
| Unknown | 0 | 19 (16%) | 10 (8%) | |
| Mode of death (n = 254) | 0.380 | |||
| Cardiac | ||||
| Sudden | 3 (27%) | 32 (27%) | 26 (21%) | |
| Non-sudden | 6 (55%) | 68 (57%) | 64 (52%) | |
| Vascular | 1 (9%) | 2 (2%) | 5 (4%) | |
| Noncardiac, nonvascular | 1 (9%) | 16 (13%) | 29 (23%) | |
| Unknown | 0 | 1 (1%) | 0 | |
| Heart weight (g): range (n = 230) | 480–880 | 305–1,050 | 310–860 | 0.107 ‡ |
| (Mean ± SD) | (622 ± 116) | (609 ± 157) | (554 ± 126) | |
| 95% CI | 538,706 | 582,636 | 527,580 | |
| Men | 480–880 | 320–1,050 | 380–860 | |
| (633 ± 116) | (638 ± 148) | (593 ± 117) | ||
| Women | 510 | 305–730 | 310–710 | |
| (483 ± 133) | (468 ± 103) | |||
| Number of enlarged hearts § (214 of 230) | 11 of 11 (100%) | 99 of 108 (92%) | 104 of 111 (94%) | 0.547 |
| Narrowing of ≥1 major coronary arteries >75% (n = 95/232) | 0 | 41 (37%) | 54 (48%) | 0.069 |
| Left ventricular (n = 254) | 0.502 | |||
| Necrosis only | 2 (18%) | 5 (4%) | 7 (6%) | |
| Fibrosis only | 4 (36%) | 38 (32%) | 41 (33%) | |
| Both | 0 | 8 (7%) | 5 (4%) | |
| Neither | 5 (45%) | 68 (57%) | 71 (57%) | |
| Calcium | ||||
| Aortic valve (n = 248) | 0.101 | |||
| 0 | 1 (9%) | 1 (1%) | 1 (1%) | |
| 1+ | 0 | 11 (9%) | 10 (8%) | |
| 2+ | 3 (27%) | 18 (16%) | 14 (12%) | |
| 3+ | 5 (45%) | 27 (23%) | 33 (27%) | |
| 4+ | 2 (18%) | 59 (51%) | 63 (52%) | |
| Mitral annulus (n = 88 of 242) | 0 | 36 (32%) | 52 (44%) | 0.059 |
| Coronary arteries (n = 119 of 230) | 1 (10%) | 34 (33%) | 84 (71%) | 0.001 |
† Symptoms include heart failure, angina pectoris, and syncope, or any combination of the 3.
‡ Age groups 36 to 65 versus >65 p value = 0.042.
| Variable | Heart Weight (g) | Unadjusted ∗ p Value | ||
|---|---|---|---|---|
| ≤400 | 401–600 | >600 | ||
| n = 26 (11%) | n = 108 (46%) | n = 100 (43%) | ||
| Age in years: range (n = 230) | 47–90 | 23–99 | 16–89 | 0.021 |
| (Mean ± SD) | 67 ± 11 | 66 ± 15 | 59 ± 15 | |
| Men/Women (n = 231) | 8/18 31%/69% | 76/29 72%/28% | 91/9 91%/9% | 0.001 |
| Aortic valve structure (n = 234) | 0.202 | |||
| Unicuspid | 2 (8%) | 11 (10%) | 20 (20%) | |
| Bicuspid | 11 (42%) | 53 (49%) | 45 (45%) | |
| Tricuspid | 13 (50%) | 44 (41%) | 35 (35%) | |
| Symptoms † (n = 234) | 0.031 | |||
| Symptomatic | 12 (46%) | 62 (57%) | 78 (78%) | |
| Asymptomatic | 8 (31%) | 31 (29%) | 11 (11%) | |
| Unknown | 6 (23%) | 15 (14%) | 11 (11%) | |
| Mode of death (n = 234) | 0.659 | |||
| Cardiac | ||||
| Sudden | 9 (35%) | 21 (19%) | 23 (23%) | |
| Non-sudden | 8 (31%) | 57 (53%) | 62 (62%) | |
| Vascular | 2 (8%) | 2 (2%) | 3 (3%) | |
| Noncardiac, nonvascular | 7 (27%) | 26 (24%) | 11 (11%) | |
| Unknown | 0 | 2 (2%) | 1 (1%) | |
| Narrowing of ≥1 major coronary arteries >75% (n = 92/213) | 11 (42%) | 43 (40%) | 38 (38%) | 0.922 |
| Left ventricular (n = 234) | 0.729 | |||
| Necrosis only | 1 (4%) | 10 (9%) | 3 (3%) | |
| Fibrosis only | 9 (35%) | 28 (26%) | 42 (42%) | |
| Both | 0 | 6 (6%) | 8 (8%) | |
| Neither | 16 (62%) | 64 (59%) | 47 (47%) | |
| Calcium | ||||
| Aortic valve (n = 229) | 0.261 | |||
| 0 | 0 | 0 | 3 (3%) | |
| 1+ | 4 (15%) | 8 (8%) | 6 (6%) | |
| 2+ | 3 (12%) | 20 (19%) | 10 (10%) | |
| 3+ | 7 (27%) | 29 (28%) | 27 (27%) | |
| 4+ | 12 (46%) | 47 (45%) | 53 (54%) | |
| Mitral annulus (n = 80/223) | 11 (42%) | 35 (32%) | 34 (34%) | 0.558 |
| Coronary arteries (n = 110/211) | 16 (62%) | 55 (51%) | 39 (39%) | 0.578 |
† Symptoms include heart failure, angina pectoris, and syncope, or any combination of the 3.
| Variable | Coronary Narrowing (Cross-Sectional Area) | Unadjusted ∗ p Value | |
|---|---|---|---|
| >75% | <75% | ||
| n = 96 (41%) | n = 138 (59%) | ||
| Age in years: range (n = 232) | 42–99 | 16–90 | 0.001 |
| (Mean ± SD) | 68 ± 12 | 61 ± 15 | |
| Men/Women (n = 233) | 74/21 78%/22% | 99/39 72%/28% | 0.292 |
| Aortic valve structure (n = 234) | 0.018 | ||
| Unicuspid | 6 (6%) | 30 (22%) | |
| Bicuspid | 43 (45%) | 63 (46%) | |
| Tricuspid | 47 (48%) | 45 (33%) | |
| Symptoms † (n = 234) | 0.161 | ||
| Symptomatic | 67 (69%) | 96 (70%) | |
| Asymptomatic | 15 (16%) | 31 (22%) | |
| Unknown | 14 (15%) | 11 (8%) | |
| Mode of death (n = 234) | 0.245 | ||
| Cardiac | |||
| Sudden | 26 (27%) | 31 (22%) | |
| Non-sudden | 47 (49%) | 80 (58%) | |
| Vascular | 5 (5%) | 2 (1%) | |
| Noncardiac, nonvascular | 17 (18%) | 25 (18%) | |
| Unknown | 1 (1%) | 0 | |
| Heart weight (g): range (n = 212) | 305–1,050 | 310–960 | 0.222 |
| (Mean ± SD) | 566 ± 137 | 590 ± 142 | |
| Men | 320–1,050 | 380–960 | |
| 593 ± 132 | 630 ± 130 | ||
| Women | 305–730 | 310–710 | |
| 472 ± 118 | 473 ± 105 | ||
| Number of enlarged hearts ‡ (n = 197 of 212) | 85 of 91 (93%) | 112 of 121 (93%) | 0.813 |
| Left ventricular (n = 234) | 0.001 | ||
| Necrosis only | 7 (7%) | 5 (4%) | |
| Fibrosis only | 49 (51%) | 28 (20%) | |
| Both | 8 (8%) | 4 (3%) | |
| Neither | 32 (33%) | 101 (73%) | |
| Calcium | |||
| Aortic valve (n = 234) | 0.464 | ||
| 0 | 0 | 3 (2%) | |
| 1+ | 10 (10%) | 9 (7%) | |
| 2+ | 13 (14%) | 22 (16%) | |
| 3+ | 22 (23%) | 35 (25%) | |
| 4+ | 51 (53%) | 69 (50%) | |
| Mitral annulus (n = 81/231) | 39 (41%) | 42 (30%) | 0.112 |
| Coronary arteries (n = 111/221) | 64 (67%) | 47 (34%) | 0.001 |
† Symptoms include heart failure, angina pectoris, and syncope, or any combination of the 3.
| Patient | Age (Years) | Gender | Number of AV Cusps | AV Calcium | Interval from Cath to Death (Days) | Left Ventricle | Aorta | PSG (mm Hg) | Heart Weight (g) | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Systolic (mm Hg) | Diastolic (mm Hg) | Systolic (mm Hg) | Diastolic (mm Hg) | ||||||||
| 1 | 32 | F | 1 | 4+ | 34 | 172 | 26 | 82 | 66 | 90 | 510 |
| 2 | 33 | M | 1 | 3+ | 24 | 135 | 50 | 120 | 60 | 15 | 880 |
| 3 | 34 | M | 1 | 3+ | 37 | 184 | 36 | 92 | 68 | 92 | 570 |
| 4 | 39 | M | 1 | 4+ | 40 | 162 | 25 | 96 | 66 | 66 | 750 |
| 5 | 57 | M | 1 | 4+ | 670 | 202 | 18 | 122 | 72 | 80 | 630 |
| 6 | 60 | M | 1 | 1+ | 30 | — | — | — | — | 60 | — |
| 7 | 16 | M | 2 | 3+ | 11 | 230 | 8 | 105 | 75 | 125 | 680 |
| 8 | 37 | M | 2 | 4+ | 365 | 146 | 37 | 96 | 74 | 50 | 750 |
| 9 | 42 | F | 2 | 2+ | 10 | 240 | 12 | 115 | 65 | 125 | 420 |
| 10 | 52 | M | 2 | 3+ | 30 | — | — | — | — | 80 | 630 |
| 11 | 52 | F | 2 | 4+ | 1 | 230 | 30 | 100 | 70 | 130 | 700 |
| 12 | 54 | M | 2 | 4+ | 30 | 238 | 37 | 90 | 70 | 148 | 850 |
| 13 | 54 | M | 2 | 4+ | 2 | 192 | 10 | 63 | 34 | 129 | 700 |
| 14 | 56 | M | 2 | 3+ | 30 | 191 | 24 | 104 | 61 | 87 | — |
| 15 | 58 | M | 2 | 1+ | 60 | — | — | — | — | 20 | — |
| 16 | 59 | M | 2 | 4+ | 720 | 200 | 12 | 155 | 60 | 45 | 580 |
| 17 | 59 | M | 2 | 2+ | 1 | — | — | — | — | 35 | 470 |
| 18 | 60 | F | 2 | 4+ | 15 | — | — | — | — | 110 | 680 |
| 19 | 61 | M | 2 | 4+ | 2 | 165 | 40 | 111 | — | 54 | 630 |
| 20 | 67 | M | 2 | 2+ | 730 | 202 | 7 | 175 | 95 | 27 | — |
| 21 | 67 | M | 2 | 4+ | 30 | — | 35 | — | — | 55 | 740 |
| 22 | 67 | M | 2 | 4+ | 90 | — | 8 | — | — | 72 | 680 |
| 23 | 68 | M | 2 | 1+ | 522 | 123 | 20 | 112 | 59 | 11 | 550 |
| 24 | 75 | F | 2 | 4+ | 1 | — | — | — | — | 125 | — |
| 25 | 77 | M | 2 | 4+ | 2 | — | — | — | — | 50 | 570 |
| 26 | 44 | M | 3 | 4+ | 9 | — | — | — | — | 82 | 590 |
| 27 | 49 | M | 3 | 4+ | 12 | 188 | 20 | 114 | 48 | 74 | 710 |
| 28 | 51 | M | 3 | 2+ | 720 | — | — | — | — | 20 | 960 |
| 29 | 62 | M | 3 | 3+ | 1 | — | — | — | — | 15 | 500 |
| 30 | 66 | M | 3 | 4+ | 30 | 182 | 40 | 120 | 60 | 62 | 655 |
| 31 | 71 | M | 3 | 2+ | 570 | — | — | — | — | 20 | 800 |
| 32 | 76 | F | 3 | 4+ | 1 | — | — | — | — | 60 | — |
| 33 | 77 | F | 3 | 3+ | 90 | 180 | 4 | 115 | — | 65 | 380 |
| 34 | 79 | M | 3 | 3+ | 8 | 150 | 10 | 120 | 80 | 30 | 505 |
| 35 | 61 | M | 2 | 4+ | 90 | — | — | — | — | 100 | 530 |
| 36 | 60 | M | 2 | — | 180 | 197 | 12 | 186 | 72 | 11 | 540 |
| 37 | 70 | M | 2 | — | 92 | — | — | — | — | 93 | — |
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