Background and aim
Fractional flow reserve (FFR) is routinely used for coronary lesion assessment. Maximal coronary vasodilatation can be accomplished by intracoronary (IC) and intravenous (IV) adenosine (the gold standard), IC-nitroprusside (NTP) or IC-papaverine. We compared FFR response to IC-NTP vs. IV-adenosine.
Methods
Nitroprusside 100 μg bolus was injected over <3 s (two repeated injections 60 s apart). Sixty seconds after last NTP injection, continuous intravenous administration of adenosine (140 μg/kg/m) was initiated for 150 s. The FFR was measured using conventional FFR wire (Prime Wire, Volcano) and guiding catheters (6F Cordis guides with or without side holes).
Methods
Nitroprusside 100 μg bolus was injected over <3 s (two repeated injections 60 s apart). Sixty seconds after last NTP injection, continuous intravenous administration of adenosine (140 μg/kg/m) was initiated for 150 s. The FFR was measured using conventional FFR wire (Prime Wire, Volcano) and guiding catheters (6F Cordis guides with or without side holes).
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