Introduction/Objectives
The key role of inflammation in the pathogenesis and progression of atherosclerotic vascular disease is well established, and leucocyte count is a robust marker of inflammation. High preoperative total leukocyte count (TLC) has been shown to predict mortality, complications and major adverse cardiac events (MACE) following percutaneous coronary intervention and cardiac and carotid surgery. We evaluated the effect of high preoperative TLC on mortality and postoperative MACE following nonemergent thoracic aortic surgery.
Methods
We retrospectively analyzed the predictors of 30-day mortality and MACE in patients undergoing thoracic aortic repair using the NSQUIP database from 2006 to 2007. Patients undergoing emergent surgery were excluded. Outcomes measured were all-cause mortality and MACE (composite of myocardial infarction, stroke or all-cause mortality) within 30 days of surgery. We used univariate analysis ( χ 2 /ANOVA) and multivariate logistic regression for statistical analysis.
Methods
We retrospectively analyzed the predictors of 30-day mortality and MACE in patients undergoing thoracic aortic repair using the NSQUIP database from 2006 to 2007. Patients undergoing emergent surgery were excluded. Outcomes measured were all-cause mortality and MACE (composite of myocardial infarction, stroke or all-cause mortality) within 30 days of surgery. We used univariate analysis ( χ 2 /ANOVA) and multivariate logistic regression for statistical analysis.
Results
A total of 127 patients were included in the study, and all underwent open surgical repair as per the discretion of the treating surgeon. The mean age of the population was 69 years, and 81 (64%) were males. By the end of 30 days, 16 (13%) patients died and 20 (16%) patients had MACE. Age, smoking status, chronic obstructive pulmonary disease, chronic renal insufficiency and elevated TLC were independently predictive of 30-day mortality in the multivariate analysis. The independent predictors of MACE were age, chronic renal insufficiency and elevated TLC. Elevated TLC was the single most important predictor of 30-day mortality and MACE.
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