Everolimus-eluting stents inhibit neointimal macrophage foam cell accumulations in the coronary arteries of familial hypercholesterolemic swine




Background


The influence of drug-eluting stents (DES) on atherosclerotic lesion progression or regression is not well characterized. We used a balloon preinjury, familial hypercholesterolemic swine (FHS) model to study the impact of everolimus-eluting stents on early lesion formation, specifically, the accumulation of lipid-laden macrophages (foam cells) and neointimal thickening.




Methods


Synergy TM (everolimus in a biodegradable polymer, n =7) and Promus Element TM everolimus-eluting stents ( n =6) were compared to Element TM bare metal stents (BMS, n =7)) in 8-month-old FHS swine coronary arteries. Arteries received three 30-s 30% balloon overstretch inflations prior to stent placement. Stented specimens were retrieved after 30 days, and standard morphometric assessment was used to determine neointimal thickness and the area of macrophage foam cell accumulation in the intima. Statistical significance was calculated using one-way ANOVA.

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Nov 16, 2017 | Posted by in CARDIOLOGY | Comments Off on Everolimus-eluting stents inhibit neointimal macrophage foam cell accumulations in the coronary arteries of familial hypercholesterolemic swine

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