Does gradual discontinuation of clopidogrel ameliorate the potential for enhanced platelet rebound activity post sudden stoppage?




Background


Late stent thrombosis remains a major concern with drug-eluting stents (DES). Retrospective analysis of such cases has shown a clustering of such events post sudden stoppage. Prior studies have shown a potential for enhanced platelet aggregation as a mechanism.




Aim


The aim of this work is to compare the platelet aggregation between sudden stopping (group A) vs. gradual stopping of clopidogrel over a 2-week period (group B) using the current gold standard light transmission aggregometry (LTA).




Aim


The aim of this work is to compare the platelet aggregation between sudden stopping (group A) vs. gradual stopping of clopidogrel over a 2-week period (group B) using the current gold standard light transmission aggregometry (LTA).

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Nov 16, 2017 | Posted by in CARDIOLOGY | Comments Off on Does gradual discontinuation of clopidogrel ameliorate the potential for enhanced platelet rebound activity post sudden stoppage?

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