Clopidogrel low response and correlation between the different tests: light transmission aggregometry, VerifyNow P2Y12, and VASP




Background


Clopidogrel low response correlates with poor prognosis after percutaneous coronary intervention (PCI). Many biological tests are currently available to test the clopidogrel response. However, the presence of any correlation between the different tests is today poorly reported.




Methods


In this prospective study, clopidogrel response was assessed in 100 consecutive patients after PCI. All patients were tested between 18 h and 24 h after a 600-mg clopidogrel loading dose using three different tests: light transmission aggregometry with 10 μmol ADP (LTA, results expressed as platelet inhibition percentage), VerifyNow-P2Y12 (VN, results expressed as PRU), and vasodilatator stimulated phosphoprotein (VASP, results expressed as IRP). Patients under chronic clopidogrel therapy were excluded.




Methods


In this prospective study, clopidogrel response was assessed in 100 consecutive patients after PCI. All patients were tested between 18 h and 24 h after a 600-mg clopidogrel loading dose using three different tests: light transmission aggregometry with 10 μmol ADP (LTA, results expressed as platelet inhibition percentage), VerifyNow-P2Y12 (VN, results expressed as PRU), and vasodilatator stimulated phosphoprotein (VASP, results expressed as IRP). Patients under chronic clopidogrel therapy were excluded.

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Nov 16, 2017 | Posted by in CARDIOLOGY | Comments Off on Clopidogrel low response and correlation between the different tests: light transmission aggregometry, VerifyNow P2Y12, and VASP

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