Circulating platelet microparticles: a potential predictive marker for the severity of peripheral arterial diseases




Aim


The aim was to determine the relationship between platelet activation (represented in PMPs CD 63 and CD 62) and the severity of PAD.




Patients and methods


This is a prospective study conducted along the period of June 2008 to June 2009 on patients with lower extremity peripheral vascular disease due to atherosclerosis or other cause of arteriopathy (e.g., Buerger’s disease) together with 15 age-/sex-matched healthy controls. Patients were divided into two groups: Group (Gr.) A: patients with moderate disease (intermittent claudication IC) and Group (Gr.) B: patients with severe disease [rest pain and/or tissue loss, i.e., critical limb ischemia (CLI)]. Platelet-poor plasma from the venous samples was subjected to flow cytometry to detect PMPs. Exclusion criteria included refusal of consent, renal failure, presence of coexisting inflammatory diseases, liver cirrhosis, heart failure and history of cancer.




Patients and methods


This is a prospective study conducted along the period of June 2008 to June 2009 on patients with lower extremity peripheral vascular disease due to atherosclerosis or other cause of arteriopathy (e.g., Buerger’s disease) together with 15 age-/sex-matched healthy controls. Patients were divided into two groups: Group (Gr.) A: patients with moderate disease (intermittent claudication IC) and Group (Gr.) B: patients with severe disease [rest pain and/or tissue loss, i.e., critical limb ischemia (CLI)]. Platelet-poor plasma from the venous samples was subjected to flow cytometry to detect PMPs. Exclusion criteria included refusal of consent, renal failure, presence of coexisting inflammatory diseases, liver cirrhosis, heart failure and history of cancer.

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Nov 16, 2017 | Posted by in CARDIOLOGY | Comments Off on Circulating platelet microparticles: a potential predictive marker for the severity of peripheral arterial diseases

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