Ablation of Nonpulmonary Vein Triggers




Abstract


Nonpulmonary vein (non-PV) “triggers” can be identified in 10% to 33% of unselected patients with atrial fibrillation (AF). Compared with paroxysmal AF, the incidence of non-PV foci is higher in patients with persistent AF. Ablation of non-PV triggers is also important for patients with persistent AF and for those patients who undergo repeat ablation procedures in whom all PVs are found to be isolated. Accurate mapping/localization of non-PV triggers is a prime step and can be achieved with a systematic approach based on the analysis of the P wave morphology, intraatrial activation patterns at multipolar catheters in the standardized position of both atria, and the earliest activation site with direct recording. Ablation should be targeted at a specific site of origin or isolation of certain non-PV structures including superior vena cava, coronary sinus, posterior wall of the left atrium, and left atrial appendage.




keywords

atrial fibrillation, catheter ablation, electrode mapping, nonpulmonary vein trigger, superior vena cava

 




Key Points





  • Nonpulmonary vein (non-PV) “triggers” can be identified in 10% to 33% of unselected patients with atrial fibrillation (AF).



  • Compared with paroxysmal AF, the incidence of non-PV foci is higher in patients with persistent AF.



  • Ablation of non-PV triggers is also important for patients with persistent AF and for those patients who undergo repeat ablation procedures in whom all PVs are found to be isolated.



  • Accurate mapping/localization of non-PV triggers is a prime step and can be achieved with a systematic approach based on the analysis of the P wave morphology, intraatrial activation patterns at multipolar catheters in the standardized position of both atria, and the earliest activation site with direct recording.



  • Ablation should be targeted at a specific site of origin or isolation of certain non-PV structures including superior vena cava, coronary sinus, posterior wall of the left atrium, and left atrial appendage.





Incidence of Nonpulmonary Vein Triggers


Most ectopic beats that trigger paroxysmal atrial fibrillation (AF) originate from pulmonary veins (PVs); therefore PV isolation (PVI) is an established procedure. However, recurrences without reconnection of PV have also been noted; thus many studies have demonstrated the importance of non-PV foci. Non-PV “triggers” can be identified in 10% to 33% of unselected patients referred for catheter ablation of AF. The prevalence of non-PV triggers in different studies varies with the specific definition adopted, which ranges from repetitive atrial premature depolarizations without definitive AF initiation to reproducibly triggering sustained AF. The incidence of non-PV foci is higher in patients with persistent AF and coexisting medical conditions, including chronic lung disease, than in those with paroxysmal AF. During redo ablation, non-PV triggers can be identified in nearly half of the patients. Non-PV triggers can be provoked in patients with both paroxysmal and more persistent forms of AF. In selected patients with reproducible non-PV triggers and without provocative PV triggers receiving high-dose isoproterenol (5–20 μg per minute), elimination of only the non-PV triggers has resulted in elimination of AF. Supraventricular tachycardias, such as atrioventricular (AV) nodal reentry or accessory pathway–mediated AV reciprocating tachycardia, can also be identified in up to 4% of unselected patients referred for AF ablation and can serve as a triggering mechanism for AF.




Origins of Nonpulmonary Vein Triggers


Mapping studies of non-PV foci have demonstrated that triggers are typically clustered in discrete anatomic regions that have been shown to contain cardiomyocytes that can exhibit arrhythmogenic activity. The superior vena cava (SVC) contains an atrial muscle extension from the embryonic sinus venous tissue capable of spontaneous ectopic activity and has been shown to be one of the most important sites of non-PV triggers. The posterior wall of the left atrium (LA) is known to be an extension of the PVs and becomes one of the important non-PV trigger foci. Diseased human atria show low diastolic potential and altered cellular responses compared with normal atria. This may account for abnormal automaticity or triggered activity arising from the posterior free wall of the LA. The ligament of Marshall (LOM) is a remnant of the left SVC that contains nerves, fibrous tissues, and muscle bundles (Marshall bundles) that directly connect to the atrial myocardium and coronary sinus (CS) muscle sleeves. Hwang et al. reported that this could be a potential source of triggers and drivers for AF, and catheter ablation of LOM is feasible and clinically useful. Myocardial fibers within the CS have also been reported to have triggered activity, which may serve either as a trigger for AF or as a part of a reentrant circuit. The crista terminalis (CT) is an area of marked anisotropy because of poor transverse cell-to-cell coupling, and such anisotropy, by creating a region of slow conduction, favors the development of macro- or microreentry. In addition, the normal sinus pacemaker complex is distributed along the long axis of the CT, which contributes to the automaticity. The interatrial septum, particularly at its muscular portion at the level of the fossa ovalis, has been reported to be another potential trigger site for AF. More recently, frequent and repetitive premature atrial depolarizations have been identified in the LA appendage (LAA) in patients with more persistent AF, which have been targeted by LAA isolation techniques.




Provocation and Mapping of Nonpulmonary Vein Triggers


Withholding of antiarrhythmic agents for five half-lives and withholding beta-blockers for at least 24 hours is important when a strategy of searching for non-PV triggers is used. A typical protocol for initiating non-PV triggers includes:



  • 1.

    If the patient presents with AF, cardioversion is performed to restore sinus rhythm (SR) and check for spontaneous AF reinitiation with the specific aim of identifying postcardioversion AF triggers.


  • 2.

    If the presenting rhythm is SR or if AF is not spontaneously reinduced after cardioversion, the following protocol is performed: (1) graded infusion of isoproterenol at up to 20 to 30 μg per minute for at least 10 minutes is recommended; (2) if no effect is observed with isoproterenol infusion, burst pacing for AF and then cardioversion during isoproterenol infusion (2–10 μg per minute) may be considered. Pacing for AF induction is performed using 15-beat drive train at an amplitude of 10 mA and a pulse width of 2 ms, decrementing by 10 ms from 250 to 180 ms or failure to capture with a 5-second pause between drives. Multiple cardioversions are typically necessary to see reproducibility of immediate reinitiation of AF postcardioversion.


  • 3.

    Adenosine bolus (12–18 mg) or burst atrial pacing is used during lower-dose isoproterenol infusion to attempt to identify repetitive triggers after the drive train.


  • 4.

    The end point of protocol to assess the effect of ablation for evaluating non-PV triggers is the inability to “trigger” AF with repeat isoproterenol or adenosine infusion.



The approach used to map non-PV triggers includes analysis of the initiating P wave morphology on the 12-lead electrocardiogram (ECG), analysis of the earliest endocardial site of activation at the multipolar CS and CT/SVC catheters referenced to the P wave onset, and detailed mapping of the origin outside the PVs by manipulating the circular mapping catheter and the ablation catheter ( Figs. 16.1–16.3 ) in the LA and right atrium (RA).




Fig. 16.1


Suggested stepwise algorithm for localization of the origin of nonpulmonary vein (non-PV) triggers of atrial fibrillation based on the P wave (PW) morphology of the 12-lead ECG. CS , Coronary sinus; CT , crista terminalis; ECG , electrocardiogram; ER , Eustachian ridge; In , inferior; LA , left atrial; LAA , left atrial appendage; Lat , lateral; LOM , ligament of Marshall; MA , mitral annulus; Med , medial; PW , P wave; RA , right atrial; RAA , right atrial appendage; Sept , septal; SR , sinus rhythm; Sup , superior; TA , tricuspid annulus.

Modified from Santangeli P, Marchlinski FE. Techniques for the provocation, localization, and ablation of non-pulmonary vein triggers for atrial fibrillation. Heart Rhythm 2017;14(7):1087-1096.



Fig. 16.2


An algorithm for differential diagnosis of the nonpulmonary vein ectopy initiating atrial fibrillation (AF) and reentrant-type AF. CSd, Distal portion of coronary sinus; CSp, proximal portion of coronary sinus; CT, crista terminalis; HIS, His bundle area; HRA, high right atrium; LA, left atrium; LOM, ligament of Marshall; L-PV, left pulmonary vein; R-PV, right pulmonary vein; SVC, superior vena cava. Δ (HRA–HIS) represents the time interval from the high right atrial electrogram onset to the onset of the His atrial electrogram during sinus beats minus the same interval measured during ectopic atrial activity. CSp–CSd represents the difference in time of activation between the proximal and distal CS atrial electrograms during an ectopic atrial beat.

Modified from Higa S, Tai CT, Chen SA. Catheter ablation of atrial fibrillation originating from extrapulmonary vein areas: Taipei approach. Heart Rhythm 2006;3(11):1386-1390.



Fig. 16.3


Fluoroscopic views illustrating the standard multielectrode catheter position for mapping triggers (A, left anterior oblique 30-degree view and B, right anterior oblique 30-degree view). Anatomic relation between the left atrium and the esophagus by barium swallowing is also illustrated. A quadripolar catheter is positioned at the NCC for the reference of 3-dimensional mapping system (EnSite NavX/Velocity, Abbott-St. Jude Inc).

CS , Coronary sinus; Eso, esophagus; NCC, noncoronary cusp; RA, right atrium; RSPV, right superior pulmonary vein; SVC, superior vena cava.


Potentials from both SVC and right superior PV (RSPV) can be recorded as far-field potentials rather than a local potential because the two structures are close in proximity. Thus the positioning of a catheter in SVC is obligatory when the trigger from a right-sided PV is evaluated.


After circumferential ablation of left-sided PVs, the potential recorded on multielectrode catheter inside each of the correspondent PVs should be evaluated to check whether PVs remain connected or LOM potential is exposed. The pacing maneuver in different sites (LAA and distal CS) is required to identify the presence of LOM potential. If the potentials are caused by connection through LOM between LA and CS epicardially, conduction delay can be observed in LAA pacing but not in distal CS pacing ( Figs. 16.4 and 16.5 ).




Fig. 16.4


Occlusive venography of coronary sinus (CS) to reveal vein of Marshall (VOM) between CS and great cardiac vein (GCV) on right anterior oblique (A) and left anterior oblique (B) views. The ostium of VOM is located at CS immediately distal to a balloon catheter and VOM noted between anterior aspect of left inferior pulmonary vein (LIPV) ostium and mitral annulus.



Fig. 16.5


Direct recording of ligament of Marshall (LOM) potential by a multielectrode catheter positioned epicardially (A). After circumferential ablation of left-sided pulmonary veins, a discrete potential from LOM is noted at epicardial catheter during sinus rhythm (B), from proximal to distal sequence. Pacing at different sites (coronary sinus [CS], panel C and left atrial appendage [LAA], panel D) confirms the presence of LOM potential. The conduction delay is observed in LAA pacing (D) but not in CS pacing (C). LOM potential is eliminated during delivery of radiofrequency at the ostium of vein of Marshall (E). EPIp , proximal electrodes of the epicardial ablation catheter; GCV , great cardiac vein.


Catheters need to be moved to differentiate the site of interest. In case of non-PV triggers near the CS ostium, the catheters have to move into the septum of the RA and CS ostium to localize the trigger site. Every effort should be made to prevent mechanical ectopy by confirming stable catheter position and to avoid manipulating the catheters during induction of arrhythmias.




Ablation of Nonpulmonary Vein Triggers


Superior Vena Cava


The proximal SVC contains myocardium that connects to the RA, and thus atrial excitation or sinus node impulses can propagate into the SVC, and vice versa. SVC cardiomyocytes were found to have pacemaker activity, and the enhanced automaticity and after-depolarization play a role in the arrhythmogenic activity of SVC.


Typically, the P wave from the SVC will have a larger negative component in lead V1 than a right PV, which originates more posteriorly (see Fig. 16.1 ). The SVC can be divided into three parts. The first part extends from the junction of the right and left brachiocephalic veins to the upper end of the right pulmonary artery. The second part involves the SVC that is crossed posteriorly by the right pulmonary artery (i.e., from the upper border of the right pulmonary artery to the lower border of the right pulmonary artery). The third part begins from the lower end of the second part and extends to the site of the RA–SVC junction, which is defined as the point below which the cylindrical SVC flares into the RA ( Fig. 16.6 ). The SVC-RA junction can be confirmed using an SVC venogram, intracardiac echocardiography (ICE), and electrical signals. An SVC trigger displays the earliest activation from the muscular sleeve of the SVC, followed by distal to proximal SVC electrograms and atrial electrograms ( Fig. 16.7 ). A differential diagnosis between SVC triggers and triggers from nearby structures is challenging because of the close anatomic proximity between the SVC and other structures, such as the RSPV and the superior CT. In rare instances, a direct muscular connection between the RSPV and the SVC can be demonstrated with pacing maneuvers (i.e., intercaval bundle). In these cases, the distinction between a trigger from SVC and RSPV can be established only after RSPV isolation (with entrance and exit block) is accomplished.




Fig. 16.6


Coronal scout view of the superior caval vein. The measurements of the superior caval vein were performed after cross-sectioning at the different levels of the superior caval vein. The cross-section of the superior caval vein revealed an eccentric and nonround shape. Ao , Aorta; LA , left atrium; PA , pulmonary artery; R-PA , right pulmonary artery; S , superior caval vein.

Modified from Huang BH, Wu MH, Tsao HM, et al. Morphology of the thoracic veins and left atrium in paroxysmal atrial fibrillation initiated by superior caval vein ectopy. J Cardiovasc Electrophysiol . 2005;16(4):411-417.



Fig. 16.7


Spontaneous initiation of atrial fibrillation originating from the superior vena cava (SVC). (A) Position of multielectrode catheters at SVC and right superior pulmonary vein (RSPV), indicated by arrows . (B) Discrete potential from SVC preceded the far-field atrial activities from RSPV. II, aVF and V1, Surface electrocardiographic leads; D, distal; CSd, distal coronary sinus; CSp, proximal coronary sinus.


For AF patients with an SVC trigger, electrical isolation of the SVC from the RA at the level of the RA–SVC junction is a preferable approach to avoid recurrence and SVC stenosis. The end point is the electrical conduction block from the RA to the SVC (entrance block). The exit block of the focal repetitive activity inside the SVC may be observed before and after ablation. A 3-dimensional mapping system can facilitate the electrical isolation of the SVC. The junction between the SVC and the RA can be easily imaged with ICE to guide positioning of the circular mapping catheter. When the circular mapping catheter is placed, radiofrequency (RF) energy should be applied just proximally to the circular mapping catheter. When delivering RF energy to the anterolateral SVC ostium, special caution is required. Increase in sinus node automaticity may be a warning sign of impending injury to the sinus node. It is crucial to pace the distal electrode of the ablation catheter at a high current level (minimum of 20 mA) to check the phrenic nerve stimulation before energy is delivered to the SVC or lateral RA wall to prevent phrenic nerve injury. It is also advisable to monitor the right hemidiaphragm fluoroscopically during ablation. In contrast to wide-area PVI, a segmental approach targeting the earliest breakthrough on the circular mapping catheter in the SVC is most commonly used.


Crista Terminalis


Atrial triggers originating from the superior portion of the CT result in similar P wave morphology and the intracardiac atrial activation sequence, as in SVC or a RSPV trigger (see Figs. 16.1 and 16.2 ). The activation sequence of a trigger from the superior CT does not display earliest activation at the distal poles of the SVC catheter, and the activation sequence of the double potentials in the SVC region is not reversed. Triggers from the inferior portion of the CT have early activation at the more proximal poles of the CT catheter. The intracardiac activation for inferior CT triggers spreads centrifugally from the more proximal poles of the CT catheter to the rest of the RA and CS poles in a proximal to distal sequence. For AF patients with triggered activity from the CT, a focal ablation targeting the earliest activation of the ectopy is performed until the trigger is completely eliminated. The CT trigger is usually located around the transverse gap in the CT, which shows double potentials during SR. For patients who have accompanying RA atypical flutter involving the transverse gap in the CT, linear ablation is performed around the gap to eliminate the trigger and to block transverse conduction through this gap. ICE is helpful to clarify the anatomic relation between the CT and the catheter position during ablation. Pacing at high output to delineate the course of the right phrenic nerve is mandatory before applying RF energy in the CT region, particularly along its mid-superior portion.


Eustachian Ridge


The Eustachian ridge is the inferior continuation of the CT and is known to have pacemaker cells, which can be a source of abnormal automaticity leading to atrial tachyarrhythmias including AF. Triggers from the Eustachian ridge region have a P wave morphology and intracardiac activation patterns that are similar to cavotricuspid isthmus–dependent RA flutters, particularly when a prior cavotricuspid isthmus ablation line has been performed (see Fig. 16.1 ). Catheter ablation at the Eustachian ridge region can also be facilitated by direct imaging with ICE.


Coronary Sinus


The muscular portion of the CS, which ends with insertion of the valve of Vieussens, serves either as a trigger for AF or as a part of a reentrant circuit. The vein of Marshall (VOM) terminates in the LOM and inserts into the CS at the level of the valve of Vieussens. A CS trigger can be identified from a multielectrode catheter inserted into the CS, which needs to be differentiated from the LOM trigger, LAA, or mitral annulus. A CS trigger is characterized by negative P waves in the inferior leads (II, III, and aVF) and biphasic/positive P wave in lead V1, flat to negative P wave in lead V6 from CS ostial trigger or positive P wave in lead V1, and negative P wave in leads V4-V5 from the body of the CS (see Fig. 16.1 ). In patients with AF triggered from the CS, electrical disconnection of the CS to the atrium by endocardial (from the LA) or epicardial (within the CS) ablation, or both, is a preferable approach. A circular catheter or 3D mapping system is useful for the ablation procedure. The disappearance or isolation of the CS that triggers AF is the end point. Irrigated RF energy is recommended for ablation within the CS to allow for effective RF delivery and to minimize the risk of impedance increases. In general, ablation within the CS is performed at 25 to 30 W, with temperature not exceeding 40ºC. When ablating within the CS, close monitoring of the esophageal temperature is needed, and the tip of the ablation catheter should be kept facing the LA (posterior) aspect of the CS in the right anterior oblique projection, to minimize the damage to the left circumflex artery.


Ligament of Marshall


The most reliable method to detect a trigger from the LOM is via direct cannulation from the CS with a small multipolar catheter ( Fig. 16.8 ). In the absence of direct recordings from the LOM, a LOM trigger is suspected in the presence of (1) early activation in the mid-CS near the ostium of the VOM; (2) relatively broad early endocardial activation in the posterolateral LA between the mid-CS and the left inferior PV; and (3) an early endocardial activation in the ridge between the LAA and the left superior PV. P wave morphology analysis is unable to predict a LOM trigger with adequate reliability, although some ECG criteria have been suggested (see Fig. 16.1 ). In the presence of a LOM trigger, complete electrical isolation of the LOM is the optimal ablation end point. This could be achieved endocardially by targeting the perimitral area between the mitral annulus near the mid-CS and the anterior antrum of the left PV. If the endocardial approach fails to eliminate the LOM trigger, direct RF delivery near the VOM either within the CS or using the epicardial approach is required to complete LOM isolation (see Fig. 16.5 and Table 16.1 ). Recently, a technique for LOM ablation using a direct ethanol injection in the VOM through an angioplasty wire and balloon has been reported to be effective.




Fig. 16.8


Direct recording of vein of Marshall ( VOM ) using a multielectrode catheter during sustained atrial fibrillation. Fractionated electrograms, indicated by a red box in panel B , were identified during atrial fibrillation.


TABLE 16.1

Results of Radiofrequency Catheter Ablation of Atrial Fibrillation Originating From the Ligament of Marshall












































































































Study No. of Patients Mean Age (y) by Gender Mapping Tool Mapping Site Ablation Sites (No. of Patients) Ablation Method Multiple Foci Success Complications Recurrence Follow-Up (MO)
Katritsis et al. 10 54.2 ± 9.4 (NA) C LA, CS LA (4), CS (1), LA/CS (5) Focal Yes 7 (70.0%)† 1 (10%)‡ NA 11 ± 5
Polymeropoulos et al. 1 66(F) CARTO LA, CS LA Focal Yes Yes No No 3
Lin et al. 6 66 ± 13 (NA) LA, CS LSPV (6); ostium (5), inside (1) Focal 5 (83%) 3 (50.0%) No 3 (50.0%) NA
Hwang et al. 21 43.2 ± 8.7 5(F) / 16(M) Microelectrode VOM VOM insertion sites Focal Yes 18 (85.7%) No 2 (11.1%) 19 ± 10
Kurotobi et al. 11 NA C LA Distal end of VOM (LA posterior 5, lateral 4, roof 2) Focal NA 11 (100%) NA NA NA
Chang et al. 20 51 ± 12 (M) NavX RA, LA (15) Focal Yes Yes NA 70% 46 ± 23
Lo et al. 20 53 ± 11 (M) NavX LA LPV os, Posterolateral Focal Yes Yes No NA 48 ± 23

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Feb 21, 2019 | Posted by in CARDIOLOGY | Comments Off on Ablation of Nonpulmonary Vein Triggers

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