Introduction

Retinoic acid (RA), the active form of vitamin A (retinol), acts through specific nuclear receptors inducing expression of specific genes. Retinoid receptors are expressed in vascular smooth muscle cells and RA is known to have inhibitory effects on the proliferation of these cells. Here we investigated for the first time the safety and efficacy of a cobalt chromium retinoic acid-eluting stent (RES) with a biodegradable polymer.

Methods

Cobalt chromium stents (10 mm length, Medispes SA, Greece), bare (group BARE, n =6), coated with a biodegradable poly(lactide-co-glycolide) (PLGA)-based polymer (group POL, n =6), coated with PLGA and a relatively low dose of 6 μg RA (group LOW, n =8), and coated with PLGA and a relatively high dose of 24 μg RA (group HIGH, n =5), were implanted in the iliac arteries of New Zealand rabbits. After 28 days, the animals were sacrificed and histomorphometric analysis was performed.

Only gold members can continue reading. Log In or Register to continue

Share this:

• Click to share on Twitter (Opens in new window)
• Click to share on Facebook (Opens in new window)

Related

Related posts:

1. Successful collapse vessel treatment with a syringe for thrombus-aspiration after the guidewire-induced coronary artery perforation
2. Anterograde recanalisation of the radial artery followed by transradial angioplasty
3. Individualized cerebrospinal fluid drainage for preventing spinal cord ischemia in secondary TEVAR for type B dissection
4. The plaque morphology of restenosis in DES versus BMS assessed by virtual histology

Stay updated, free articles. Join our Telegram channel

Join

Full access? Get Clinical Tree