(1)
Orthopaedic Surgery, Allegheny Health Network, Pittsburgh, PA, USA
(2)
Orthopedic and Plastic Surgery, Mayo Clinic, Rochester, MN, USA
Keywords
Hand lossHand amputationUpper limb lossPartial hand amputationLimb salvageReplantationProstheticsTargeted reinnervationTargeted muscle reinnervationIntroduction
Although significantly less common than vascular insufficiency in the lower extremities, heart, and other organs, processes leading to inadequate vascular flow in the upper extremity carry significant morbidity [1]. This is largely due to the functional importance of the upper extremity to human life . It is most commonly caused by chronic progressive disease , which can usually be treated medically at first and eventually necessitating surgical management.
Limb ischemia in the upper extremity has many causes, including but not limited to acute arterial/venous injury, iatrogenic events, chronic processes (occlusive, spastic, or combined), or congenital malformations. The end result is a spectrum of decreased flow of blood and nutrition to tissues. Vascular insufficiency causes intermittent or chronic symptoms of pain, sensory changes, or ulceration [2]. Critical limb ischemia can be simply defined as ischemia causing cell death and necrosis which leads to or necessitates amputation. In the setting of acute arterial injury, arterial reconstruction is indicated in an attempt to restore flow and prevent tissue necrosis. In this chapter, we will address only management of critical limb ischemia through amputation. Amputation is indicated when revascularization has failed to restore adequate tissue perfusion and necrosis has ensued.
In the setting of vascular insufficiency requiring amputation in the upper extremity, functional rehabilitation with early return to activities of daily living is the primary goal, with secondary goals being:
- 1.
Preservation of functional length as allowed by remaining vascular flow
- 2.
Durable skin coverage
- 3.
Preservation of sensibility
- 4.
Prevention of neuroma
- 5.
Early prosthetic fitting, when applicable
- 6.
Minimize convalescence
- 7.
Early return to activity and work
- 8.
Prevention of secondary complications
Understanding the patient’s own personal goals and motivation is paramount to creating a successful treatment plan. In the case of a traumatic amputation or mangled extremity, a well-planned amputation may be favorable to a replantation when considering technical demands of the operation, potential complications, postoperative rehabilitation, time lost from work, and ultimate functional needs and outcomes for that particular patient. For nonurgent amputation in the case of chronic disease, a lengthy discussion with the patient must be had to understand attitude, functional/work needs, and commitment to treatment for that particular patient. Return to normal activities and work is a primary consideration and the surgeon must be mindful of the patient’s work, hobbies, and personal desires. There is often a balance between definitive amputation at a level of known tissue viability and preserving marginal tissue. While preserving tissue is important, some patients may be better served by early definitive surgery that enables a quicker return to work and activities. Cold intolerance is a common consequence of amputation, especially after digital loss. While symptoms can persist years later, they generally improve over time [3, 4].
Limb Salvage and Replantation
No hand is so badly crippled that, if it is painless, has sensation, and strong prehension, it is [not] far better than any prosthesis. Norman Kirk, 1944 [5]
Dr. Kirk’s statement in 1944 is as true today as it was then. For the hand surgeon, limb salvage and hand preservation are common considerations, typically presenting after severe trauma. Salvage of a functional hand may require revascularization, nerve repair, skeletal fixation, tendon repair, and/or soft tissue coverage. The goal of these procedures is to restore a pain-free, sensate hand that is capable of some sort of prehension. It is important to consider the minimum requirement that can allow prehension. This is possible with a single movable digit and some sort of post. This could mean a preserved thumb and just enough residual hand (“mitten hand”) or a thumb post and (a) movable finger(s) that can oppose. Therefore, the greatest value is placed on thumb reconstruction, even if it requires replantation of a finger in the thumb position (Fig. 51.1) or pollicization of a neighboring digit (Fig. 51.2). The thumb’s importance is recognized by work-related injury compensation where 40 % of the hand function and 25 % of total body function is attributed to the thumb.
Fig. 51.1
Shown is an infant child with severe lawn-mower injury to bilateral hands . The right hand was amputated at the radiocarpal joint (a). On the left, the radial half of the hand was amputated which included the thumb to the level of the carpometacarpal joint (b). The largest amputated part belonged to the contralateral index, middle, and ring finger (c). The middle finger was fashioned to reconstruct the left thumb, while fillet flaps were used of the neighboring digits to provide (incomplete) skin coverage (d). The patient was able to use the neo-thumb for pinch and grasp activity even in the early postoperative period (e) while the contralateral extremity served as a useful “helper hand” after revision amputation (f). Follow-up at 12 weeks demonstrates completely healed wounds with grafted areas and good motion of the neo-thumb (g, h). From Chim H, et al. Challenges in replantation of complex amputations. Semin Plast Surg, 2013. 27(4): p. 182–9. Reprinted with permission from Thieme
Fig. 51.2
Shown is the left hand of a middle-aged man who sustained a mangling table saw injury . The thumb was dysvascular and included a sagittal injury. The index finger was also dysvascular with two-level injury to the neurovascular bundles (a). The index finger was used for thumb reconstruction via pollicization, while maintaining integrity of the dorsal veins and extensor mechanism and microsurgical arterial revascularization and flexor tendon reconstruction (b–d). Later follow-up demonstrated good healing with protective sensation and functional motion (e, f)
Reattachment or replantation of the amputated part(s) often provides the best available reconstructive option. Indications for replantation include the following [6]:
Thumb
Multiple digits
Hand amputation through palm
Hand amputation (distal wrist)
Any part in a child
More proximal arm (sharp only)
Finger distal to sublimis insertion (zone I)
while contraindications include the following:
Single digits proximal to flexor digitorum superficialis insertion (zone II)
Severely crushed or mangled parts
Multiple-level amputations
Replantation in patients with multiple trauma or severe medical problems (relative contraindication)
Digits are quite tolerant of ischemia with successful revascularization reported after 33 h of warm ischemia [7] and 94 h of cold ischemia [8]. To protect the amputated part (and prevent cold injury), it should be cleansed, wrapped in moist sterile gauze, and placed in a water and airtight bag or container, which is then placed on ice. The patient and amputated part should be transferred to a level-1 trauma center with microsurgical and hand surgery expertise. Even with sharp, guillotine amputations, there is a zone of injury and modest skeletal shortening facilitates reattachment. This can be achieved by joint fusion if the amputation transections a joint, which is relatively common (Fig. 51.3). Although crush and avulsion injuries can make reattachment more challenging, these are not absolute contraindications for replantation and the digits should be considered for reattachment, excluding other contraindications. The sequence of repair is determined surgeon preference. The author’s preference typically begins with skeletal fixation, followed by tendon preparation, arterial repair, nerve repair, tendon repair, vein repair, and (loose) skin approximation. The dressing and splint are kept bulky and non-constrictive and allow for examination of the digit. Monitoring the part can be a challenge, especially if the part becomes macerated [9].
Fig. 51.3
43-year-old female with left thumb amputation through the interphalangeal (IP) joint (a–c). Modest skeletal shortening is performed and replantation (d) at the joint level and the joint is fused acutely with K-wires (e). K-wires are removed at 6 weeks after radiographic union (f, g). Skin and bone are healed at 12 weeks (h, i). Fusion at the IP joint is well-compensated in the thumb due to the mobility of the trapeziometacarpal joint (j)
Hand salvage and length preservation can make a tremendous difference in the patient’s final functional outcome. The use of spare parts for reattachment or soft tissue coverage as a fillet flap must be considered. Often the spare parts are ischemic and there will not be an opportunity for use beyond the initial operation. Again, the guiding principles are the restoration of prehension for hand injuries and maintaining length for more proximal injuries. One consideration, when using a fillet flap for residual limb coverage, is to include innervated skeletal muscle that can be used acutely for targeted muscle reinnervation for prosthetic control (Fig. 51.4). However, when considering the inclusion of muscle, one must consider the ischemia time of the tissue, as the metabolic demand of skeletal muscle is relatively high and, additionally, there may be a risk of myoglobinuria .
Fig. 51.4
73-year-old male with recurrent poorly differentiated sarcoma involving right the proximal humerus. Prior to oncologic resection, a radial forearm flap is harvested neurotized flexor muscle mass with median and ulnar nerves (a, b). Oncologic resection is then performed (c), and the flap is harvested just before the specimen is rendered ischemic (d, e). The median and ulnar nerves are coapted to the transected brachial plexus (TMR) to provide intuitive myoelectric signals for intuitive prosthetic control (f). His healing flap is shown 1 month postoperative (g)
Multiple Digit/Partial Hand Amputation
Digits threatened by vascular compromise can present significant difficulties, specifically with patient rehabilitation and disability (Fig. 51.5). Whether a single or multiple digits are to be amputated, an analysis of retained function must be made to employ the most appropriate surgical plan. Inevitably, any loss of tissue will lead to decreased function (most commonly grip strength). Interestingly, the level of amputation does not always correlate with patient disability [10]. However, it is important to recognize that amputation is irreversible. When in doubt, it is better to leave a digit that may offer some unforeseeable function as it can always be removed later with little morbidity.
Fig. 51.5
50-year-old female with diabetic nephropathy and vasculopathy with bilateral hand ischemia (a, b)
A multitude of various surgical options exist for digital amputation, ranging from simple guillotine amputation to complex reconstruction and tissue transfers. Preservation of length, soft tissue coverage, and functional sensibility are the core concepts in digital and partial hand amputations [11–15]. Postoperatively, the residual finger and/or hand is often hypersensitive. Directed hand therapy is often helpful to “desensitize” the remaining digit(s). Cold intolerance is also common, especially, when the remaining tissues may have insufficient circulation. This can be debilitating, especially in colder climates. While cold intolerance subsides with time, many patients will struggle long term. Some individuals may find it necessary to change work and/or living environments to avoid exposure to cold [3].
It should be highlighted that the thumb receives special attention due to its functional importance. It is estimated that the thumb comprises 40–50 % of overall hand function. Every effort should be made preserve the thumb. When this is not possible, thumb reconstruction should be considered. Advanced reconstructive techniques such as pollicization of a neighboring digit and toe-to-thumb transfers, can be employed, if possible and appropriate, to regain function [16, 17].
Regarding digit amputation, classically, greater value is placed on the central digits (middle and ring finger) in comparison to the border digits (index and small finger). It is easier to compensate for the loss of a border digit both functionally and cosmetically. A three-finger hand can actually look remarkably normal (Fig. 51.2) and functionally compensated. However, the loss of hand span (width) does present a loss of pronosupination strength due to loss of the lever arm length [15]. Loss of a central digit leaves a gap in the hand that is very noticeable and presents a functional problem with use of the hand as a cup or scoop. Narrowing the resultant space after central digit loss can be accomplished by ray resection with intermetacarpal ligament repair (Fig. 51.6) or ray transposition as described by Carroll and others [18, 19].
Fig. 51.6
25-year-old male sustained a gunshot wound to the right hand with skeletal destruction of the metacarpal, proximal phalanx, and joint of the ring finger (a). Definitive treatment is accomplished with ray resection and web space closure with intermetacarpal ligament repair and K-wire fixation (b). Motion is preserved without malrotation or scissoring of the neighboring digits (c, d). Postoperative appearance demonstrates acceptable closure of the webspace and good function (e, f)
Wrist Disarticulation
Amputation at the level of the wrist causing loss of the entire hand significantly decreases the overall function of the upper extremity secondary to loss of grip and intrinsic function of the hand. Creating wrist-level prosthetics is difficult and options are limited. Every option to preserve the hand must be entertained.