We report a case of Takotsubo cardiomyopathy (TC) occurring after a transesophageal echocardiography (TOE). TC is a recently described syndrome characterized by transient left ventricular (LV) dysfunction, mimicking ST-segment elevation myocardial infarction in its presentation, without obstructive coronary artery disease. Although the aetiology of TC syndrome remains obscure, stress appears to be the principal trigger. It is more common in middle-aged women, and the prognosis is favourable. TOE is considered as a semi invasive exam, but widely performed for cardiovascular evaluation with a relatively good tolerance and a very low rate of complication. We describe the case of a 65-year-old female patient who underwent a TOE and developed afterward a TC. To the best of our knowledge, this is the first case describing TC following TOE.