Thyroid Hormones and Cardiovascular Surgery


Block of variables

n

Average

SD

Minimum

Maximum

25th Quartile

Median

75th Quartile

Calculated significance (P)

Total leukocytes pre

18

7,369.44

2,629.74

2,090.00

12,450.00

5,980.00

7,180.00

9,190.00
 
Total leukocyte intra

18

11,507.22

5,950.92

2,930.00

21,100.00

6,940.00

9,255.00

18,002.50
 
Total leukocytes 24 h

18

13,738.33

3,763.50

7,990.00

23,980.00

10,655.00

13,680.00

15,275.00

<0.001

Total leukocytes 48 h

18

12,966.67

3,933.52

8,060.00

23,320.00

10,290.00

12,410.00

13,825.00
 
Total neutrophils pre

18

7,927.22

13,646.36

690,00

62,000.00

3,920.00

4,670.00

6,520.00
 
Total neutrophils intra

18

9,342.78

5,258.52

1,140.00

19,620.00

5,240.00

8,225.00

13,897.50
 
Total neutrophils 24 h

18

11,646.67

3,926.20

6,310.00

23,260.00

8,920.00

11,480.00

12,807.50

<0.001

Total neutrophils 48 h

18

10,607.11

4,655.99

858.00

20,990.00

8,145.00

9,515.00

12,522.50
 
Total platelet pre

18

244,444.44

76,814.69

130,000.00

385,000.00

177,750.00

247,000.00

307,750.00
 
Total platelet intra

18

166,277.78

62,520.40

85,000.00

311,000.00

117,000.00

160,000.00

201,500.00

<0.001

Total Platelet 24

18

160,994.44

59,754.86

73,000.00

305,000.00

122,250.00

142,500.00

209,750.00
 
Total platelet 48 h

18

160,994.44

63,178.99

83,000.00

306,000.00

129,250.00

147,500.00

223,500.00
 


A306695_1_En_31_Fig1_HTML.gif


Fig. 31.1
Comparison between time points regarding number of total leukocytes


A306695_1_En_31_Fig2_HTML.gif


Fig. 31.2
Comparison between time points regarding number of neutrophils


A306695_1_En_31_Fig3_HTML.gif


Fig. 31.3
Comparison between time points regarding number of platelets


Many authors have assumed that decreased thyroid hormones levels occurring during cardiopulmonary bypass should be preoperatively balanced by T4 or T3 supplementation. The rationale for this undertaking is prevention of negative effects from depressed cardiac output, perfusion pressure, stroke volume, and contractility intra- and postoperatively [8, 9].

Nonetheless, as pointed out previously, this matter is so intriguing that some authors, such as Velissaris et al. [10], have advocated that a reduction in thyroid hormone levels might consist of an organic adaptive process of reduced catabolism rather than a true hypothyroid state. The basis for this theory was the association between low free T3 levels and high global oxygen consumption (Fig. 31.10) [10].


Table 31.2
Comparison between the time points of simultaneous observation for total protein and albumin


















































































































Block of variables

n

Average

SD

Minimum

Maximum

25th Quartile

Median

75th Quartile

Calculated significance (P)

Total protein pre

18

6.78

0.88

5.00

7.90

6.03

7.00

7.50
 

Total protein intra

18

4.70

0.90

2.80

6.20

4.30

4.85

5.33
 

Total protein 24

18

4.85

0.58

3.20

5.70

4.58

5.00

5.13

<0.001

Total protein 48 h

18

5.11

0.68

3.20

6.40

4.88

5.10

5.40
 

Total albumins pre

18

4.05

0.56

2.80

4.90

3.73

4.10

4.40
 

Total albumins intra

18

2.72

0.53

1.70

3.60

2.33

2.75

3.20
 

Total albumins 24 h

18

2.86

0.39

2.00

3.50

2.68

2.90

3.03

<0.001

Total albumins 48 h

18

2.94

0.37

1.80

3.50

2.80

3.00

3.13
 

Jul 10, 2016 | Posted by in CARDIAC SURGERY | Comments Off on Thyroid Hormones and Cardiovascular Surgery

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