Background .– Patent ductus arteriosus is responsible for left ventricular diastolic and right ventricular systolic overload. Little is known about hemodynamic changes after percutaneous and surgical closure.

Methods .– We conducted a bicentric prospective study, of children, with patent ductus arteriosus, evaluating the evolution of systolic and diastolic ventricular function before, 1 day and 1 month after successful closure, by means of transthoracic echocardiography.

Results .– Thirty-three children, age 3 months to 14.5 years, underwent successful closure of their patent ductus arteriosus, 32 percutaneously and one surgically. All patent ductus arteriosus were closed for hemodynamic reasons, with a mean diameter of 3.6 ± 0.9 mm. There was a significant increase in systolic (100.6 ± 15.1 versus 95.4 ± 15.3 mmHg, P < 0.05) and diastolic (53.2 ± 17.1 versus 47.8 ± 17.2 mmHg, P < 0.05) blood pressures, immediately after the suppression of the shunt. Left ventricular fractional shortening and end-diastolic volumes index were significantly lower the day after closure (respectively 34.7 ± 5.5 versus 37.8 ± 4.7% and 47 ± 16.2 versus 54.6 ± 20.1 mL/m ² ) and remained low compared to the preclosure state at follow-up (respectively 33.8 ± 5.4 versus 37.8 ± 4.7% and 47 ± 12.7 versus 54.6 ± 20.1 mL/m ² ). A non-significant decrease in left ventricular filling pressures was observed. Right ventricular systolic parameters (TAPSE) were significantly lower 1 month after closure (19.3 ± 2.9 versus 21.4 ± 4.4 mm, P < 0.05).

Conclusion .– Changes in left ventricular volume and function and in right ventricular function occur immediately after patent ductus arteriosus closure, and remain at 1 month of follow-up. Further studies are warranted to increase the number of patients and the duration of follow-up.