The Fontan Operation


References

First author

Journal

Year

Design

n

Age

BMI

Male (%)

Diagnosis

APC/TCPC

NYHA

Peak VO2

ACEI/ARB

ß

Diuretics

[24]

Myers KA

JASE

2013

Fontan

22

14.9 (7.6–18.7)

19.5 (15.0–25.7)

–

TA(8), PA/IVS(4), CAVC(6), UVH(4)

NA

NA

–

64 %

18 %

5 %
    
Control

23

15.2 (7.6–18.3)

18.9 (13.0–36.6)

–

Healthy

–

–

–

–

–

–

[23]

Lambert E

Int J Cardiol

2013

Fontan

18

25±1

25±1

44

TA(4), DILV(8), CAVC(2), MA(1), other(2)

9/9

NA

–

94 %

39 %

11 %
    
Control

23

23±1

24±1

35

Healthy

–

–

–

–

–

–

[22]

Sarkola T

Heart & Vessel

2013

Fontan

28

14.8±1.3

20.4±3.1

54

SV(12), PA(11), HLHS(5)

0/28

NA

67±14(%)

50 %

13 %

NA
    
Control

54

14.8±1.6

21.3±3.8

63

Healthy

–

–
 
–

–

–

[25]

Tomkiewicz-Pajak L

CV Ultrasound

2014

Fontan

25

24.7±6.2

21.7±2

56

TA(12), PA/IVS/TGA(8), DILV(3), DORV(2)

2/23

15/18/2

–

12 %

–

NA
    
Control

25

26.9±3.4

22.6±3

60

Healthy

–

–

–

–

–

–

[30]

Kojima T, et al.

Circ J

2014

Dilated

6/31

3.5±0.7

–

58

UVH(21), PA/IVS(6), DORV(3), TA(1)

0/6

NA

–

32 %

33 %

–
    
Non-dilated

6/25

4.5±0.7

–

58

UVH(15), PA/IVS(5), DORV(3), TA(2)

0/6

NA

–

7 %

26 %

–

[35]

Saiki H

Ann Thrasic Surg

2014

Fontan

34

11.5±8.6

–

47

NA

NA

NA

–

NA

NA

NA
    
Control

20

13.4±6.0

–

60

PVC/IM/ASD/VSD

–

–

–

NA

NA

NA

[26]

Muller J

Int J Cardiol

2015

Fontan

87

23.9±10.5

21.9±5.0

57

NA

NA

NA

71.2±18.4(%)

34 %

10 %

NA
    
Control

322

29.4±18.4

23.0±4.4

49

Healthy

–

–

–

8 %

20 %

NA

[27]

Bhat DP

Pediatr Cardiol

2015

Fontan

22

13.1±4.2

22.4±6.6

50

LV-SV(12), HLHS(10)

0/22

NA

–

41 %

NA

NA
    
Control

22

13.8±2.6

21.6±4.3

68

Healthy

–

–

–

–

–

–

[29]

Ohuchi H

Int Heart J

2017

Fontan

130

18±8

19±4

61

UVH(40), TA(31), DORV(23), MA(14), others

10/120

78/42/10

54±11(%)

33 %

28 %

65 %
    
Control

36

16±6

20±3

50

VSD(29), PDA(7)

–

–

–

–

–

–


ACEI angiotensin-converting enzyme inhibitor, ARB angiotensin receptor blocker, APC atriopulmonary connection, ASD atrial septal defect, BMI body mass index, ß beta-blocker, CAVC common atrioventricular cannel, DILV double inlet left ventricle, DORV double outlet right ventricle, HLHS hypoplastic left heart syndrome, IM innocent murmur, LV–SV left ventricular-type systemic ventricle, MA mitral atresia, NA not available, NYHA New York Heart Association, PA/IVS pulmonary atresia with intact ventricular septum, PDA patent ductus arteriosus, PVC premature ventricular contraction, SV systemic ventricle, TA tricuspid atresia, TCPC total cavopulmonary connection, TGA transposition of the great arteries, UVH univentricular heart, VO 2 oxygen uptake, VSD ventricular septal defect




Table 20.2
Aortopathy-associated variables in patients after Fontan operation































































































































 
Cardiovascular variables
Aortic dimensions
Aortopathy variables

Ref erences
HR
SBP
DBP
PP
aAO
CCA
dAO
aAO/dAO
PWV
AI
aAO SI ß
CCA SI ß
dAO SI ß
aAO/dAO SI ß
TAC
CCA compliance

[24]
74(49–96)
105(82–140)
66(45–80)
38.5(29–68)
–
–
–
–
4.88(3.58–9.94)***
–
4.15(1.79–14.4)*
–
–
–
1.29(0.70–3.33)
–
 
72(55–114)
107(93–135)
64(41–74)
45(30–73)
–
–
–
–
3.64(2.68–4.85)
–
3.04(1.56–5.68)
–
–
–
1.32(0.74–4.25)
–

[23]
63±2
109±2
67±2
–
–
–
–
–
6.01±0.23
4.93±2.4†***
–
–
–
–
–
–
 
70±3*
117±2*
65±2
–
–
–
–
–
5.82±0.46
–9.81±2.27†
–
–
–
–
–
–

[22]
–
101±10*
53±9
–
–
5.02±0.51**
11.2±2.7
–
5.2±1.1(7.4±1.7)**

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Related posts:

  1. History of Aortopathy
  2. Aortopathies: Clinical Manifestation
  3. Clinical Diagnosis and Surgical Therapy of the Ascending Aorta and the Aortic Arch
  4. Imaging: Echo, CT and MRI

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Aug 30, 2017 | Posted by in CARDIOLOGY | Comments Off on The Fontan Operation

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