Results of Endovascular Mesenteric Revascularization


Author

Year

N

Clinical success (%)

Patency (%)

30 day mortality

Complications (%)

Odurney

1988

10

50

30

NR

10

Matsumoto

1995

15

80

53

NR

16

Allen

1996

18

79

89

6 %

 6

Maspes

1998

41

77

86

0

 5


NR not reported





Early Mesenteric Stent Results


From what was reported, angioplasty alone did have some benefit, but there was a real need for improvement in immediate- and longer-term results. In an effort to improve these, Ivancev’s group described the first sma stent, which included not only stenting the sma but also recanalizing a chronic total occlusion (CTO) [15]. They reported continued patency 9 months after the intervention, which was documented by angiography. Since the time of early reports, balloon angioplasty and stenting of mesenteric occlusive disease were slow to be adopted. However, with refinement in techniques, lower-profile devices, and extended training of multiple subspecialties, soon many case series described the success of PTA and stenting of the visceral vessels [16] (Table 14.2). Sheeran et al. looked at their results of PTA and stent in 12 patients, 3 of whom were chronic total occlusions. Their initial technical success was 92 %, including 3 patients with chronic occlusions. One patient died within 30 days of the procedure (mortality 8.3 %) due to bowel infarction, despite a patent stent. Primary and primary-assisted patency was 74 % and 83 % respectively, and secondary patency was 83 %. All three patients with chronic occlusions had relief of clinical signs and symptoms at a mean follow-up of 22 months. Chahid et al. reported their results after treating 14 patients [17]. Their technical success and initial clinical success was 100 %. Long-term relief of symptoms was 79 %, and two patients underwent repeat angioplasty for an absolute patency rate 86. Two major complications were observed: one hematoma and one false aneurysm occurring at the brachial puncture site (14.3 %).


Table 14.2
Early PTA and stent results




























































Author

Year

N

Clinical success (%)

Primary patency

30 day mortality

Complications

Linblad

1996

 1

100

100 % at 9 months

0

 0

Sheeran

1999

12

 92

74 %

8.3 %

8.3

Chahid

2004

14

 79

86 %

0

14.3 %

Matsumoto

2002

33

 83.3

83.3 %

0

13 %

Sharruddin

2003

25

 88

92 % at 6 months

4 %

12 %

Matsumoto reported one of the first larger series of patients [18]. He reviewed their experience of PTA and stenting in a group of 33 patients. Twenty-one patients underwent PTA alone and 12 PTA and stenting. Technical success occurred in 81 % of patients with PTA and 100 % PTA and stent. The long-term clinical success was 83.3 %, and assisted clinical success was 96.6 % as four patients underwent repeat angioplasty. Patency rates were not reported. The complication rate was 13 % and 30 day mortality 0 %. Another large series was published by Sharrudin et al. [19] They evaluated their results of mesenteric stenting in 25 patients, 21 of whom were done for chronic mesenteric ischemia. Their reported technical success was 96 %, and clinical outcomes showed primary and primary-assisted clinical benefits at 11 months of 85 % and 91 %. He also was the first to report actuarial Kaplan Meier patencies, which were both 92 % at six months. Major complications occurred in three patients for a rate of 12 %.


Mesenteric Intervention vs. Open Surgery


As minimally invasive techniques started receiving a ground swell of enthusiasm, people soon began to compare the results to the gold standard open surgery (Table 14.3). Although mesenteric bypass’ results were improving, there was still significant morbidity and mortality [20]. The first large series reported was that from the Cleveland Clinic [21]. Kasirajan et al. compared outcomes of endovascular versus open surgery; outcomes were compared between 28 patients treated with PTA and stent and 85 patients who underwent open mesenteric revascularization. Of the patients who underwent PTA and stent, 18 % had angioplasty alone and 82 % angioplasty plus stent. Of the patients who had open surgery, 71 % had bypass, 22 % transaortic endarterectomy, and 7 % local endarterectomy and patch angioplasty. Fewer vessels were revascularized per patient in the PTA and stent group (1.1) compared with the OS group (1.5). There was no difference noted in the early in-hospital complications (17.9 % vs. 32.9 %) or mortality rate (10.7 % vs. 8.2 %). However, there was a trend towards reduced length of hospital stay in the PTA stent (5 days vs. 13 days). The 3-year cumulative recurrent stenosis rates also were not different (27 % vs. 24 %), but recurrent symptoms were significantly higher in the PTA stent vs. open surgery (34 % vs. 13 %). The end result was that while PTA and stents were improving, they had not yet met the gold standard.


Table 14.3
PTA and stent vs. open surgery








































































Author

Year

Open

Endovascular

N

Clinical success (%)

1o patency (%)

30 day mortality (%)

Major morbidity (%)

N

Clinical success (%)

1o patency (%)

30 day mortality %

Major morbidity (%)

Kasirajan

2001

 85

87

24a

8

33

28

66

27a

11

18

Atkins

2007

 49

77

90

2.4

4.1

31

78

59

3.2

12.9

Oderich

2009

146

96

88

2.7

36

83

92

41

2.4

18


aRestenosis rates

Sep 23, 2016 | Posted by in CARDIOLOGY | Comments Off on Results of Endovascular Mesenteric Revascularization

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