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We appreciate the comments and viewpoints of Dr. Porres-Aguilar and Dr. Mukherjee regarding our article on the role of baseline echocardiography in the preoperative management of liver transplant candidates. We agree with their assessment that right heart catheterization (RHC) is the gold standard for diagnosis of portopulmonary hypertension and that it correlates variably with echocardiography in some patients. In our article, we observed that patients with pulmonary hypertension, as diagnosed by echocardiography, did not have worse outcomes after liver transplantation. As noted in the readers’ comments, the threshold for determining candidacy for liver transplantation in regard to pretransplant pulmonary pressure and the method for its assessment varies widely among centers. Thus, given our data, patients should not be excluded solely on the basis of the presence of mild or moderate pulmonary hypertension (PH) on baseline echocardiography and should at the very least be referred for RHC as the readers suggest. We would propose, on the basis of our data, that a right ventricular systolic pressure >60 mm Hg (suggestive of greater than moderate PH) be used as a cut-off value for referring patients for RHC. The purpose of our study was to examine the role of baseline echocardiography, and thus, unfortunately, we do not have the subsequent RHC data. Our current and future research will focus on the invasive hemodynamic assessment of PH in liver transplant candidates and the correlation with resting echocardiography to be able to better predict the etiology and severity of PH in this population.

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Dec 5, 2016 | Posted by in CARDIOLOGY | Comments Off on Reply

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