Background
Optimal platelet inhibition is critical to prevent ischemic events following percutaneous coronary intervention (PCI). However, recent studies have suggested that excessive inhibition may favor bleedings. We aimed to investigate the relationship between platelet reactivity inhibition and bleedings in patients undergoing PCI.
Methods
From 2008 to 2009, 710 patients undergoing PCI were included in this retrospective study. Patients who suffered in-hospital major bleeding ( n =20), as defined by non-coronary artery bypass graft (CABG)-related Thrombolysis In Myocardial Infarction (TIMI) major bleeding, were compared to patients who did not ( n =690). All patients received a 600-mg loading dose of clopidogrel and an intravenous 250–500-mg loading dose of aspirin. A propensity score matching 5:1 based on age, sex, body mass index, clinical presentation, access site, sheath diameter, and glycoprotein IIb/IIIa use was then performed. Platelet reactivity was assessed using the vasodilator-stimulated phosphoprotein (VASP) index.
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