Radiofrequency Ablation of Barrett’s Esophagus



Radiofrequency Ablation of Barrett’s Esophagus


Shajan Peter

C. Mel Wilcox

Klaus Mönkemüller





PATIENT HISTORY AND PHYSICAL FINDINGS



  • It might be difficult to distinguish symptoms of BE from gastroesophageal reflux disease (GERD) clinically, although increased duration, severity, and early age of onset for reflux symptoms as well as obesity predispose to BE occurrence.4


  • Age older than 55 years, male gender, white ethnicity, or smokers are predisposing factors for BE development and progression to dysplasia. Genetic influences may play a role, although only a small proportion (7%) of patients with BE have a documented family history of BE or esophageal cancer.5


  • Selection of patients for endoscopic treatment of BE requires a multidisciplinary approach consisting of the endoscopist, pathologist, and the surgeon.


  • Confirmation of dysplasia (high or low grade) on biopsies or endoscopic mucosal resection (EMR) specimens is done by a dedicated gastrointestinal (GI) pathologist.6


IMAGING AND OTHER DIAGNOSTIC STUDIES



  • Detailed endoscopic examination with high-definition white light of the BE segment is essential for management.


  • The extent of the BE segment should be defined using the Prague C & M classification including the length of the circumferential segment (C) and the maximal extent of the BE segment (M)7 (FIG 1).


  • Other imaging modalities that might help in delineating BE are narrow band imaging (NBI), chromoendoscopy, autofluorescence imaging, and confocal laser endoscopy. These adjuncts aid in directed biopsies.


  • Any visible lesions in the Barrett’s segment should be described using the Paris classification.8


  • Targeted biopsies are obtained from visible abnormalities, followed by four-quadrant biopsies of every 1 to 2 cm of the BE segment (Seattle protocol) and these should be reviewed by a dedicated GI pathologist.9 Nodular lesions are best staged by an EMR as described in Chapter 28.






FIG 1 • Prague C & M classification.


ENDOSCOPIC MANAGEMENT


Preoperative Planning



  • Patients are given standard esophagogastroduodenoscopy (EGD) preprocedure preparation instructions with specific attention to factors that increase risk of sedation including morbidly obese patients; anatomic variants such as short neck, cervical osteophytes, cricopharyngeal hypertrophy; and prior history of surgery involving the GI tract, radiation, or documentation of previous strictures.


  • No antibiotics are required and it is desirable to minimize or stop antiplatelet/anticoagulation prior to the procedure.


  • Equipment lists for circumferential and focal ablation can be found in Tables 1 and 2.


Positioning



  • The patient is placed in the left lateral decubitus position and prepared as for a routine upper endoscopy.








Table 1: Circumferential Ablation Equipment List























Endoscope and equipment


RFA energy generator console


HALO360 sizing balloon


HALO360 balloon ablation catheter


HALO cap


Gauze


1% N-acetylcysteine solution


Spray catheter


Savary spring-tipped guidewire


From Frantz DJ, Dellon ES, Shaheen NJ. Radiofrequency ablation of Barrett’s esophagus. Techniques Gastrointest Endosc. 2010;12:100-107.









Table 2: Focal Ablation Equipment List

















Endoscope and equipment


RFA energy generator


HALO90 ablation device


Gauze


1% N-acetylcysteine solution


Spray catheter


From Frantz DJ, Dellon ES, Shaheen NJ. Radiofrequency ablation of Barrett’s esophagus. Techniques Gastrointest Endosc. 2010;12:100-107.



Jul 24, 2016 | Posted by in GENERAL | Comments Off on Radiofrequency Ablation of Barrett’s Esophagus

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