Quality of Life After Carotid Stenting Versus Carotid Endarterectomy: Results From CREST (Carotid Revascularization Endarterectomy Versus Stenting Trial)

Carotid and Cerebrovascular Disease


Health-Related Quality of Life After Carotid Stenting Versus Carotid Endarterectomy: Results From CREST (Carotid Revascularization Endarterectomy Versus Stenting Trial)


Cohen DJ, on behalf of the CREST Investigators (Saint Luke’s Mid America Heart and Vascular Inst, Kansas City, MO; et al) J Am Coll Cardiol 58:1557–1565, 2011§



G.L. Moneta, MD



Evidence Ranking


• A



Expert Rating


• 3



Abstract



Objectives


The purpose of this study was to compare health-related quality of life (HRQOL) outcomes in patients treated with carotid artery stenting (CAS) versus carotid endarterectomy (CEA).



Background


In CREST (Carotid Revascularization Endarterectomy versus Stenting Trial), the largest randomized trial of carotid revascularization to date, there was no significant difference in the primary composite endpoint, but rates of stroke and myocardial infarction (MI) differed between CAS and CEA. To help guide individualized clinical decision making, we compared HRQOL among patients enrolled in the CREST study. We also performed exploratory analyses to evaluate the association between periprocedural complications and HRQOL.



Methods


We measured HRQOL at baseline, and after 2 weeks, 1 month, and 1 year among 2,502 patients randomly assigned to either CAS or CEA in the CREST study. The HRQOL was assessed using the Medical Outcomes Study Short-Form 36 (SF-36) and 6 disease-specific scales designed to study HRQOL in patients undergoing carotid revascularization.

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Apr 1, 2017 | Posted by in CARDIOLOGY | Comments Off on Quality of Life After Carotid Stenting Versus Carotid Endarterectomy: Results From CREST (Carotid Revascularization Endarterectomy Versus Stenting Trial)

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