Normal pHmonitoring
Extra-esophageal symptoms
Lack of response to acid suppression therapy
Psychiatric disorders
Obesity
Female gender
Absence of hiatal hernia
Low socioeconomic status
Since diverse symptoms respond differently to antireflux surgery, patients´ expectations must be evaluated before the operation. In a very simplistic way, patients must be alerted that the operation is excellent to esophageal symptoms (heartburn and regurgitation); moderate to extra-esophageal symptoms; and bad for gastric symptoms (bloating, epigastric pain, etc.) and the more predictors of worse outcomes are present, less likely the operation will be successful.
Proper Technique
A proper technique is essential to ensure good outcomes (Fig. 4.1).
Fig. 4.1
Technical tips for a successful laparoscopic Nissen fundoplication
Access Route
While a thoracic approach was popular in the beginning of the antireflux surgery, it evolved to be used only in cases of large hiatal hernias due to the fear that gastric reduction would be more difficult to accomplish through the abdomen; to current abandonment in favor of the abdominal route.
Laparoscopic approach to antireflux surgery started in 1991. Although some initial studies showed an increase in the rate of complications and worse outcomes compared to open operation [20], nowadays, it is common sense that the laparoscopic route is superior.
Esophageal Dissection
Although a minimal esophageal/hiatal dissection has been proposed in order to preserve natural antireflux mechanisms [21], most surgeons believe that an extensive esophageal dissection is mandatory in order to obtain 2–4 cm of esophagus without tension below the diaphragm. This manoeuver helps avoiding hernia recurrence and improve GERD control, since a long segment of abdominal esophagus is an efficient antireflux mechanism [22]. It must be in mind that each centimeter of esophagus dissected in the posterior mediastinum leads to a 0.3 centimeters gain in abdominal esophagus length [23].
Vagal trunks and branches must be carefully identified and preserved during dissection of the esophagus [14].
Hiatal Closure
Hiatal closure is a mandatory step during an antireflux operation: (1) it avoids herniation of the wrap through the hiatus and (2) the diaphragm has a synergistic action with the lower esophageal sphincter protecting against sudden increases in intra-abdominal pressure such as during coughing [24]. One of the main causes of failure after antireflux operation is gastric (wrap) herniation through the hiatus that may be attributed to breakdown of the hiatal closure or a faulty repair.
The use of prosthetic material (mesh) for hiatal reinforcement (hiatoplasty) is a controversial topic (Fig. 4.2). It brings the question of the balance between the risk of recurrence and the risk of mesh-related complications (especially esophageal and gastric erosion) [25]. While some surgeons are more liberal in the use of mesh [26], other are more selective [25]. Recent publication of the results of the late follow-up of a large multicenter trial, shows a high index of recurrence even with mesh [27].
Fig. 4.2
Methods of mesh placement (Reproduced from Herbella et al. [25], with permission from Wolters Kluwer Health, Inc.)
Fundoplication
A total fundoplication (Nissen) is the procedure of choice for most cases due to lower reflux recurrence and similar postoperative dysphagia, even in individuals with hypotensive peristalsis [28]. A partial fundoplication (Dor, Toupet) are reserved for cases with impaired peristalsis as in achalasia or scleroderma [29, 30].
Some well-established points are fundamental in achieving a good fundoplication [31].
An ideal fundoplication must be tension-free. An extensive dissection of the posterior attachments of the gastric fundus and an ample retroesophageal window are essential for this purpose. Short gastric vessels division may also help attain a floppy fundoplication. Randomized controlled trials did not show advantages when short gastric vessels are divided [32, 33]; however, in this trials a significant number of patients randomized to not divided the vessels were converted to vessel division due to intraoperative judgement of tension in the fundus after wrapping the esophagus. Moreover, some degree of tension is found in more than 50% of the cases when the short gastric vessels are not sectioned [34] justifying routine division of the vessels. An intraluminal bougie is advocate by some to calibrate the fundoplication [35]. Although one trial showed a higher incidence of dysphagia when a bougie is not used [33] (although esophageal perforation occurred due to the bougie), different series do not show advantages [36].
Another key step in this operation is the choice of the right place to create and position the wrap. Thus, gastro esophageal junction should be well identified, with the removal of the fat pad that is frequently located there, to make sure that the gastric fundus is brought around the esophagus not the stomach. Also, the gastric fundus not the gastric body should be used to create the fundoplication. Failure to this principles may lead to a faulty fundoplication.
Finally, the wrap must be short (1.5–2 cm) and floppy. Tight and long fundoplications are not associated to better reflux control but increases the risk for postoperative dysphagia and gas symptoms [37].
Proper Follow-Up
GERD does not seem to be a progressive disease where the presentation deteriorates from the nonerosive spectrum to erosive to Barrett’s esophagus to esophageal adenocarcinoma [38]. Thus, a periodic and perennial follow-up is not theoretically necessary, unless a Barrett’s esophagus is present. A short follow-up; however, is essential to guarantee good outcomes based on expectations fulfillment and understanding of a normal postoperative period.
Patients must be alerted that transitory dysphagia is normal up to 3 months after a laparoscopic Nissen fundoplication, due to edema and an esophageal ileus [39]. Also, the improvement for extra-esophageal symptoms may not be immediate. New onset symptoms may occur, such as gas symptoms, but in general quality of life is not impaired and patients’ satisfaction with the operation is sustained [5].
The need for continued usage of medication after antireflux surgery is used as an argument against the operation [40]. Most of the patients on medications after a Nissen fundoplication; however, do not have an objective indication for continued antacid therapy since the majority of patients with postoperative symptoms are either not tested for reflux or have a normal pH-monitoring; the medication is often prescribed for the treatment of symptoms not attributable to GERD, such as nasal and abdominal symptoms; primary-care physicians or gastroenterologists do not to discontinue the medications after the operation; or patients restart their medications by themselves [5].
Conclusion
We believe that Nissen fundoplication, after more than 50 years of age, can be considered a very successful creation. It treats a high proportion of cases; brings excellent results in more than 80% of the patients; improves patients’ quality of life and seems to prevent the progression of Barrett’s esophagus to adenocarcinoma [5]. Unfortunately, patients are still not offered surgical therapy based on some untrue concepts that still misguide indications for surgery and bad results when basic principles are not followed.
In conclusion, laparoscopic Nissen fundoplication is a very successful therapy for GERD with 90–96% of good and excellent results [1–4]; however, these results only come with a proper preoperative workup, patient selection, surgical technique and follow-up (Fig. 4.3).
Fig. 4.3
Road to a successful laparoscopic Nissen fundoplication
References
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2.
Eubanks TR, Omelanczuk P, Richards C, Pohl D, Pellegrini CA. Outcomes of laparoscopic antireflux procederes. Am J Surg. 2000;179(5):391–5.CrossRefPubMed