Pre-eclampsia: A Multifaceted Disorder of Pregnancy



Fig. 24.1
Schematic of pathogenesis of pre-eclampsia, based on current evidence. The decreased low-resistance shunting of maternal blood, due to a disruption of the maternal-fetal interface, at the placenta has profound effects on maternal vascular adaptations to pregnancy. In a patient with susceptible endothelium, this leads to the development of the clinical syndrome of pre-eclampsia





References



1.

Abalos E, Cuesta C, Grosso AL et al (2013) Global and regional estimates of pre-eclampsia and eclampsia: a systematic review. Eur J Obstet Gynecol Reprod Biol 170(1):1–7CrossRefPubMed


2.

Task Force on Hypertension in Pregnancy (2013) Hypertension in pregnancy: American College of Obstetricians and Gynecologists. Hypertension in Pregnancy: Executive Summary Obstetrics & Gynecology 122(5):1122–1131. doi: 10.​1097/​01.​AOG.​0000437382.​03963.​88


3.

Duley L (2009) The global impact of pre-eclampsia and eclampsia. Semin Perinatol 33(3):130–137CrossRefPubMed


4.

Turner JA (2010) Diagnosis and management of pre-eclampsia: an update. Int J Wom Health 2:327–337CrossRef


5.

Zhou Y, Fisher SJ, Janatpour M et al (1997) Human cytotrophoblasts adopt a vascular phenotype as they differentiate. A strategy for successful endovascular invasion? J Clin Invest 99(9):2139–2151CrossRefPubMedCentralPubMed


6.

Damsky CH, Fisher SJ (1998) Trophoblast pseudo-vasculogenesis: faking it with endothelial adhesion receptors. Curr Opin Cell Biol 10(5):660–666CrossRefPubMed


7.

Browne JC, Veall N (1953) The maternal placental blood flow in normotensive and hypertensive women. J Obstet Gynaecol Br Emp 60(2):141–147CrossRefPubMed


8.

Brosens IA, Robertson WB, Dixon HG (1972) The role of the spiral arteries in the pathogenesis of pre-eclampsia. Obstet Gynecol Ann 1:177–191


9.

Pijnenborg R, Dixon G, Robertson WB, Brosens I (1980) Trophoblastic invasion of human decidua from 8 to 18 weeks of pregnancy. Placenta 1(1):3–19CrossRefPubMed


10.

Pijnenborg R, Bland JM, Robertson WB et al (1981) The pattern of interstitial trophoblastic invasion of the myometrium in early human pregnancy. Placenta 2(4):303–316CrossRefPubMed


11.

Lyall F, Robson SC, Bulmer JN (2013) Spiral artery remodeling and trophoblast invasion in pre-eclampsia and fetal growth restriction: relationship to clinical outcome. Hypertension 62(6):1046–1054CrossRefPubMed


12.

Kovo M, Schreiber L, Bar J (2013) Placental vascular pathology as a mechanism of disease in pregnancy complications. Thromb Res 131(Suppl 1):S18–S21CrossRefPubMed


13.

Stevens DU, Al-Nasiry S, Bulten J, Spaanderman ME (2012) Decidual vasculopathy and adverse perinatal outcome in pre-eclamptic pregnancy. Placenta 33(8):630–633CrossRefPubMed


14.

Staff AC, Dechend R, Redman CW (2013) Review: pre-eclampsia, acute atherosis of the spiral arteries and future cardiovascular disease: two new hypotheses. Placenta 34(Suppl):S73–S78CrossRefPubMed


15.

Norwitz ER, Schust DJ, Fisher SJ (2001) Implantation and the survival of early pregnancy. N Engl J Med 345(19):1400–1408CrossRefPubMed


16.

Palei AC, Spradley FT, Warrington JP et al (2013) Pathophysiology of hypertension in pre-eclampsia: a lesson in integrative physiology. Acta Physiol (Oxf) 208(3):224–233CrossRef


17.

Hunkapiller NM, Gasperowicz M, Kapidzic M et al (2011) A role for Notch signaling in trophoblast endovascular invasion and in the pathogenesis of pre-eclampsia. Development 138(14):2987–2998CrossRefPubMedCentralPubMed


18.

Doridot L, Passet B, Mehats C et al (2013) Pre-eclampsia-like symptoms induced in mice by fetoplacental expression of STOX1 are reversed by aspirin treatment. Hypertension 61(3):662–668CrossRefPubMed


19.

van Dijk M, Mulders J, Poutsma A et al (2005) Maternal segregation of the Dutch pre-eclampsia locus at 10q22 with a new member of the winged helix gene family. Nat Genet 37(5):514–519CrossRefPubMed


20.

Berends AL, Bertoli-Avella AM, de Groot CJ et al (2007) STOX1 gene in pre-eclampsia and intrauterine growth restriction. BJOG 114(9):1163–1167CrossRefPubMed


21.

Hering L, Herse F, Geusens N et al (2010) Effects of circulating and local uteroplacental angiotensin II in rat pregnancy. Hypertension 56(2):311–318CrossRefPubMed


22.

Cui Y, Wang W, Dong N et al (2012) Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy. Nature 484(7393):246–250CrossRefPubMedCentralPubMed


23.

Colucci F, Boulenouar S, Kieckbusch J, Moffett A (2011) How does variability of immune system genes affect placentation? Placenta 32(8):539–545CrossRefPubMedCentralPubMed


24.

Verdonk K, Visser W, Van Den Meiracker AH, Danser AH (2014) The renin-angiotensin-aldosterone system in pre-eclampsia: the delicate balance between good and bad. Clin Sci (Lond) 126(8):537–544CrossRef


25.

Salas SP, Marshall G, Gutierrez BL, Rosso P (2006) Time course of maternal plasma volume and hormonal changes in women with pre-eclampsia or fetal growth restriction. Hypertension 47(2):203–208CrossRefPubMed

Only gold members can continue reading. Log In or Register to continue

Stay updated, free articles. Join our Telegram channel

Apr 13, 2017 | Posted by in CARDIOLOGY | Comments Off on Pre-eclampsia: A Multifaceted Disorder of Pregnancy

Full access? Get Clinical Tree

Get Clinical Tree app for offline access