Introduction
Drugs can lead to cardiomytoxic adverse effects. Doxorubicin can an important example such these drugs. Preventive methods are also investigated for protecting cardiomyocytes in patients who need to use cardiotoxic drugs. Therefore, we investigated the effects of hyperbaric oxygen (HBO2) therapy in experimental model with drug induced cardiotoxicity.
Method
Four equal rat groups were created with 6 rats in each group. Control group is created for obtaining the basic serum oxidant levels and nature cardiac tissue of rat genus. Sham group was created for evaluating the HBO2 therapy effects alone (2.5 atmospheric 100% oxygen therapy, 90min/day for one week). Cardiotoxicity groups were created as group I (30 mg/kg single dose doxorubicin application), group II (2.5 atmospheric 100% oxygen therapy, 90min/day for one week before 30 mg/kg single dose doxorubicin application and 2.5 atmospheric 100% oxygen therapy, 90min/day for one week after drug application). After completion of protocols, rats were venous blood samples and hearts were obtained from each groups.
Method
Four equal rat groups were created with 6 rats in each group. Control group is created for obtaining the basic serum oxidant levels and nature cardiac tissue of rat genus. Sham group was created for evaluating the HBO2 therapy effects alone (2.5 atmospheric 100% oxygen therapy, 90min/day for one week). Cardiotoxicity groups were created as group I (30 mg/kg single dose doxorubicin application), group II (2.5 atmospheric 100% oxygen therapy, 90min/day for one week before 30 mg/kg single dose doxorubicin application and 2.5 atmospheric 100% oxygen therapy, 90min/day for one week after drug application). After completion of protocols, rats were venous blood samples and hearts were obtained from each groups.
Findings
Despite the slightly increment found in sham group there is not any difference between control and sham group in regards of serum oxidative stress markers. The highest serum oxidative marker levels obtained in Group II. Nevertheless partially healthy myocardial tissue detected microscopically in this group. Although moderate oxidative stress marker increment determined in group I, the most obvious myocardial destruction was found in this group (p=0.005).
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