Objective
Although the reports are also present demonstrating the exact opposite, general opinion is that vitamin D has favorable effects on cardiovascular system. The association between vitamin D insufficiency and coronary artery disease, heart failure and hypertension were well demonstrated. Nevertheless the impact of vitamin D insufficiency on arrhythmia remains unclear.
Methods
Low vitamin D and control groups consisted of 74 and 80 patients respectively. Parameters of arrhythmia including QT and P wave dispersion, SDNN (standard deviation of all normal R-R intervals), SDNN-index (the mean of the standard deviation of normal 5-minute RR intervals), pNN50 (consecutive R-R intervals differ by more than 50 msec), RMSSD (root mean square of the successive differences), HF (High-frequency power) and LF (Low-frequency power) as well as the number of atrial pre-systole, atrial pair, supraventricular tachycardia, ventricular pre-systole, ventricular pair, non-sustained ventricular tachycardia, sustained ventricular tachycardia were compared between the patients with vitamin D insufficiency and controls.
Methods
Low vitamin D and control groups consisted of 74 and 80 patients respectively. Parameters of arrhythmia including QT and P wave dispersion, SDNN (standard deviation of all normal R-R intervals), SDNN-index (the mean of the standard deviation of normal 5-minute RR intervals), pNN50 (consecutive R-R intervals differ by more than 50 msec), RMSSD (root mean square of the successive differences), HF (High-frequency power) and LF (Low-frequency power) as well as the number of atrial pre-systole, atrial pair, supraventricular tachycardia, ventricular pre-systole, ventricular pair, non-sustained ventricular tachycardia, sustained ventricular tachycardia were compared between the patients with vitamin D insufficiency and controls.
Results
Maximum QTc, minimum QTc, QTc dispersion, maximum p wave, minimum p wave, p wave dispersion, SDNN, SDNN index, RMSSD, pNN50, HF and LF values were found to be similar between low vitamin D and control groups (p>0,05). Furthermore there was not a significant difference in the number of atrial pre-systole, atrial pair, supraventricular tachycardia, ventricular pre-systole, ventricular pair, non-sustained ventricular tachycardia and sustained ventricular tachycardia (p>0,05). Additionally, serum vitamin D levels were not found to be correlated with QTc dispersion and SDNN (r=-0,010, p=0,933 and r=-0,034, p=0,777 respectively). Multivariate linear regression analysis included age, gender, smoking status, body mass index, systolic and diastolic blood pressure and serum sodium, potassium, total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol, triglyceride and hemoglobin levels. We evaluated the effect of these variables on QT dispersion and SDNN and did not detect any independent risk factors for QT dispersion and SDNN.
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