Objective
Heart failure with reduced ejection fraction (HFREF) is closely associated with high mortality and morbidity rates. HFREF is frequently associated with renal failure. Oxidative stress and inflammation are two pathological processes which have important role in the pathophysiology of HFREF. The aim of this study is to evaluate the oxidative stress and inflammation process in patients with HREF and renal failure.
Methods
Forty two patients with HFREF and ischemic heart disease were included to the study. Glomerular filtration rates (GFR) were estimated by using MDRD formula. Patients were grouped according to GFR values higher or lower than 60 mL/min/1.73m2. Oxidative stress level was evaluated by malonic dialdehyde (MDA) levels and high sensitive CRP levels.