Background

Carbohydrate antigen 125 (CA125) is a glycoprotein marker which is synthesized by epithelial serous cells. It is frequently used in ovarian cancer diagnosis and treatment monitoring. However, it has been shown that CA 125 increases in some non-malignant conditions. Its function is not fully known. It has been shown to be correlated with functional capacity and some echocardiographic parameters in acute heart failure. However, its role for prediction of left ventricular ejection fraction (EF) has not been evaluated.

Methods

Forty two patients with reduced ejection fraction heart failure (HFREF) were consecutively enrolled to the study. Patients were followed up at least 3 months and identified as stable and compensated HF. Control group was consisted of 40 volunteers who did not have systolic and/or diastolic heart failure. Echocardiographic parameters e.g. ejection fraction were recorded. The patients were grouped as LVEF greater or lower than 50%. The predictive value of CA 125 for LVEF<50% was evaluated by using ROC curve analysis.

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