Objectives
Psoriasis is a chronic inflammatory disorder which affects around 1-3% of the human population worldwide. Cardiovascular events are the leading cause of morbidity and mortality in patients with psoriasis. Some studies have reported that psoriasis is related to increased arrhytmias. However, there is insufficient information about ventricular repolarization features in patients with psoriasis. Tp-e interval and Tp-e/QT ratio have been accepted as new markers for the assessment of myocardial repolarization and ventricular arrhythmogenesis. In this study, we evaluated ventricular repolarization features using the Tp-e interval and Tp-e/QT ratio in patients with psoriasis.
Methods
The study population consisted of 74 psoriasis patients and 74 sex and aged matched healthy volunteers. The diagnosis of psoriasis was based on a clinical or histopathological examination of all patients. QT interval, corrected QT (QTc), QT dispersion (QTd) were measured from the 12-lead electrocardiogram. The Tp-e interval was measured via the tail method. In this method, the Tp-e interval was defined as the time from the peak to the end of the T wave. V2 lead was used for measurements of the the Tp-e interval. The Tp-e/QT ratio was calculated from these measurements. These parameters were compared between groups.
Methods
The study population consisted of 74 psoriasis patients and 74 sex and aged matched healthy volunteers. The diagnosis of psoriasis was based on a clinical or histopathological examination of all patients. QT interval, corrected QT (QTc), QT dispersion (QTd) were measured from the 12-lead electrocardiogram. The Tp-e interval was measured via the tail method. In this method, the Tp-e interval was defined as the time from the peak to the end of the T wave. V2 lead was used for measurements of the the Tp-e interval. The Tp-e/QT ratio was calculated from these measurements. These parameters were compared between groups.
Results
According to the electrocardiographic parameters QT, QTc, QTd were significantly higher in patients with psoriasis (p<0,001, p<0,001, p=0,014, respectively). Tp-e interval, corrected Tp-e and Tp-e/QT ratio were significantly higher in patients with psoriasis compared to control subjects. (93±13 milliseconds [ms] vs 98±14 ms, p = 0,040; 104±17 ms vs 111±17 ms p = 0,008; 0,23±0,03 vs 0,25±0,03 p < 0,001; respectively)(Table 1). Additionally, there was a positive correlation between CRP and QT, QTc, QTd, Tp-e, Tp-e/QT ratio (p=0,012, p=0,025, p=0,020, p<0,001, p=0,001, respectively).
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