Introduction
Vitamin D may play a role in pathogenesis of atrial fibrillation (AF). Proposed mechanisms include the indirect effect of vitamin D on the atria through RAS and modulation in levels of reactive oxygen species, which contribute to inflammation and proarrhythmic substrate formation [a]. The Framingham Heart Study showed no association between 25(OH)D levels and AF in either original or offspring cohorts [44] and no association has been demonstrated between 25(OH)D levels and different types of AF (either paroxysmal, persistent, or permanent) [45]. Other studies have shown significantly lower 25(OH)D levels in patients with nonvalvular AF [46]; those with levels <50 nmol/L have a twofold higher incidence of nonvalvular AF than those with levels >75 nmol/L [47]. Another observational study showed vitamin D deficiency to be associated with new-onset AF in a hypertensive cohort [48]. The relationship between 25-Hydroxyvitamin D and development of atrial fibrillation after coronary artery bypass surgery (CABG) has not been studied.
Aim
Therefore, we assessed the relationship between the 25-Hydroxyvitamin D score and development of atrial fibrillation after CABG
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