PP-139 Assessment of Tpe, Tpe Dispersion, Tpe/QT and Tpe/QTc Ratios as Novel Markers of Ventricular Repolarization in Subclinical Hypothyroidism




Background


Thyroid disorders have many unfavorable effects on the cardiovascular system. The Tpeak–Tend interval (Tpe), Tpe dispersion (Tped), Tpe/QT and Tpe/QTc ratios are new ventricular repolarization markers and their increase is associated with increased mortality. The aim of the present study was to evaluate these new ventricular repolarization markers in subclinical hypothyroidism (SH).2




Methods


32 patients with marked SH (median age 43 [19-54] years) and 27 healthy volunteers (median age=41 [25-67] years) were enrolled. Tpe interval, Tpe dispersion, QT and corrected QT intervals (QTc), QT dispersion (QTd), QTc dispersion (QTcd), Tpe/QT ratio and Tpe/QTc ratios were obtained from the 12-lead electrocardiogram. These markers were compared between groups.




Results


QTc, QTcd, Tpe, Tped, Tpe/QT and Tpe/QTc ratios were significantly increased in SH patients compared with the control subjects (respectively, p= 0.019, 0.02, < 0.001, < 0.001, < 0.001, < 0.001). There were significant positive correlations of Tpe, Tped, Tpe/QT and Tpe/QTc ratios with TSH values (respectively, p< 0.001; r= 0.7, 0.63, 0.66, 0.7).




Conclusions


QTd, QTcd, Tpe, Tped, Tpe/QT, and Tpe/QTc increase in patients with SH. There are correlations between these markers and TSH values.



Table 1

The demographic characteristics, hormonal values and echocardiographic findings of the patients and controls



























































Variables Patients with SCH N=32 Controls N=26 P
Age, years 43 (19-54) 41 (25-67) 0.95
Sex, M/F 6/26 6/20 0.46
BMI, kg/m2 26.37±5.87 25.95±4.75 0.23
SBP, mmHg 117.25±12.63 115.38±16.83 0.17
DBP, mmHg 71.03± 9.09 71.76 ±8.54 0.77
TSH, μIU/ml (0.27-4.2) 5.7 (4.26-15) 1.6 (0.89-3.9) <0.001
fT4, ng/ml (0.93-1.7) 1.18±0.19 1.3±1.19 0.017
EF, % 65.03±7.21 68.57±4.81 0.036
LVDD,mm 45.11±4.23 44.57±3.68 0.71
LVSD, mm 28.70±3.97 26.80±2.71 0.038

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Nov 27, 2016 | Posted by in CARDIOLOGY | Comments Off on PP-139 Assessment of Tpe, Tpe Dispersion, Tpe/QT and Tpe/QTc Ratios as Novel Markers of Ventricular Repolarization in Subclinical Hypothyroidism

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