PP-138 Assessment of Tp-e interval and Tp-e/QT Ratio in Patients with Celiac Disease




Background and Aims


Celiac disease is a chronic immune-mediated disease of the small bowel. It has been known that dilated cardiomyopathy and ischemic coronary artery disease have become more frequent in patients with Celiac disease. Incidence of ventricular arrhythmia is more frequent in patients with these cardiac diseases than in the normal population. We aimed to assess of Tp-e interval and Tp-e/QT ratio as predictors of ventricular arrhythmias in patients with Celiac disease.




Methods


Totally 38 patients with Celiac disease and 38 control subjects were enrolled to the present study. Tp-e interval, Tp-e/QT and Tp-e/QTc ratio were measured from the 12-lead electrocardiogram.




Methods


Totally 38 patients with Celiac disease and 38 control subjects were enrolled to the present study. Tp-e interval, Tp-e/QT and Tp-e/QTc ratio were measured from the 12-lead electrocardiogram.




Results


Tp-e interval (64.2 ± 11.0 vs. 44.5 ± 6.0; p<0.001), Tp-e/QT ratio (0.18 ± 0.02 vs. 0.13 ± 0.02; p<0.001) and Tp-e/QTc ratio (0.16 ± 0.02 vs. 0.11 ± 0.01; p<0.001) were significiantly higher in patients with Celiac disease than control subjects(Table 1 and Figure 1).




Conclusion


Our study showed that Tp-e interval, Tp-e/QT and Tp-e/QTc ratios were increased in patients with Celiac disease.



Table 1





















































































































































Parameters Celiac disease (n=38) Controls (n=38) p value
Age, years 42.9 ± 13.1 46.6 ± 8.8 0.148
Female, n (%) 25 (65.7) 26 (68.4) 0.807
Smoking, n (%) 6 (15.7) 5 (13.1) 0.744
Alcohol, n (%) 1 (2.6) 1 (2.6) 1.000
Body mass index, kg/m2 24.7 ± 5.2 24.3 ± 5.0 0.714
Hemoglobin, g/dl 13.7 ± 1.6 13.6 ± 1.2 0.838
Creatinine, mg/dl 0.76 ± 0.15 0.82 ± 0.10 0.076
Glucose, mg/dl 95 ± 12 96 ± 12 0.667
Aspartate aminotransferase, IU/l 23.7 ± 9.7 27.9 ± 8.1 0.124
Alanine aminotransferase, IU/l 26.2 ± 15.0 29.5 ± 8.4 0.371
Total cholesterol, mg/dl 172.5 ± 37.7 189.8 ± 42.7 0.101
LDL cholesterol, mg/dl 100.0 ± 34.4 111.7 ± 36.2 0.209
HDL cholesterol, mg/dl 50.6 ± 11.6 55.7 ± 10.1 0.080
Triglyceride, mg/dl 106.6 ± 47.5 114.4 ± 47.3 0.527
ESR, mm/h 13.0 ± 9.0 5.8 ± 1.7 <0.001
CRP, mg/l 1.9 ± 1.6 1.0 ± 0.7 0.012
Anti-gliadin Ig A, +/- 22/16 – –
Anti-gliadin Ig G, +/- 16/22 – –
Anti-tissue Transglutaminase Ig A, +/- 20/18 – –
Anti-tissue Transglutaminase Ig G, +/- 4/34 – –
Disease duration, years 7.0 ± 5.7 – –
Heart rate, bpm 77.0 ± 14.3 80.2 ± 16.6 0.364
Tp-e interval, ms 64.2 ± 11.0 44.5 ± 6.0 <0.001
QT interval, ms 350.0 ± 32.5 340.7 ± 28.4 0.192
QTc interval, ms 393.8 ± 26.7 387.3 ± 34.9 0.370
Tp-e/QT ratio 0.18 ± 0.02 0.13 ± 0.02 <0.001
Tp-e/QTc ratio 0.16 ± 0.02 0.11 ± 0.01 <0.001
EF, % 60.5 ± 2.7 61.4 ± 3.0 0.257

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Nov 27, 2016 | Posted by in CARDIOLOGY | Comments Off on PP-138 Assessment of Tp-e interval and Tp-e/QT Ratio in Patients with Celiac Disease

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