Introduction
Ulcerative colitis (UC) and Crohn’s disease (CD) are chronic inflammatory bowel diseases (IBD) in which the underlying etiologic mechanisms have not been properly clarified. Among the extra intestinal complications, cardiac events might uncommonly develop. In particular, cardiac conduction system abnormalities such as prolongation the duration of (ECG waves), P, QT and QTc, and an increase in dispersion of P and QTc have been emphasized in few studies including adult patients with IBD. In the present study, we aimed to investigate the alterations in durations of P, QT and QTc in the ECGs obtained from children with IBD.
Material-Method
Thirty-six IBD (UC or CD) patients aged between 3-18 years who have been followed-up in our pediatric gastroenterology department within remission phase for at least 12 months were included into the study. The control group consisted 36 age and sex matched healthy children. Patients with preexisting structural heart diseases were excluded. The ECGs obtained from study groups were up-loaded to computer by high-resolution optical scanner. ECGs were studied with 0.02 msn mistake for heart rate (HR), minimum (min) and maximum (max) wave durations and dispersions (Pmin, Pmax, Pdisp, QTmin, QTmax, QTdisp, QTcmin, QTcmax, QTcdisp). Data were analyzed by IBM-SPSS Statistics-Vers.21 program. Student’s t-test, a parametric test, was used to compare means for data distributed normally. P<0.05 value was accepted as statistically significant.
Material-Method
Thirty-six IBD (UC or CD) patients aged between 3-18 years who have been followed-up in our pediatric gastroenterology department within remission phase for at least 12 months were included into the study. The control group consisted 36 age and sex matched healthy children. Patients with preexisting structural heart diseases were excluded. The ECGs obtained from study groups were up-loaded to computer by high-resolution optical scanner. ECGs were studied with 0.02 msn mistake for heart rate (HR), minimum (min) and maximum (max) wave durations and dispersions (Pmin, Pmax, Pdisp, QTmin, QTmax, QTdisp, QTcmin, QTcmax, QTcdisp). Data were analyzed by IBM-SPSS Statistics-Vers.21 program. Student’s t-test, a parametric test, was used to compare means for data distributed normally. P<0.05 value was accepted as statistically significant.
Results
The patient group had 21 UC and 15 CD patients. In both study groups males was %42 (n=17), females was % 52,8 (n=19). The mean age was12,09±4,48 in patients, and 12.11±4.48 in controls (p>0.05). There was no statistically significant difference between the two groups for weight, height and BMI (p=0,93; p=0,65; p=0,45). The mean values of Pmin (t=-2,707; p=0,009), Pmax (t=3,141; p=0,002) and Pdisp (t=7,451; p=0) were found statistically different. Although there was no significant difference between the mean values of QTmin and QTmax durations (p=0,06; p= 0,86), QTdisp (t=6,967; p=0) was statistically significant. QTcmin (t=-2,36; p=0,02) and QTcdisp (t=6,49; p=0) were statistically different between patient and control groups (Table1).
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