PP-089 Paraoxonase and Arylesterase Activities in Dipper and Non-dipper Prehypertensive Subjects




Objective


Paraoxonase 1, a high-density lipoprotein (HDL) linked enzyme complex, was shown to be decreased in several cardiovascular diseases. We aimed to explore whether serum paraoxonase and arylesterase activities differ in dipper and non-dipper prehypertensive subjects compared to healthy controls.




Methods


Sixty prehypertensive subjects and 30 controls enrolled in the study. All subjects underwent echocardiographic assessment and 24-hr ambulatory blood pressure monitoring (ABPM). According to ABPM, prehypertensive subjects were categorized into two: non-dipper prehypertensive (NDPH) and dipper prehypertensive (DPH) groups. Serum paraoxonase and arylesterase activities were detected spectrophotometrically.




Methods


Sixty prehypertensive subjects and 30 controls enrolled in the study. All subjects underwent echocardiographic assessment and 24-hr ambulatory blood pressure monitoring (ABPM). According to ABPM, prehypertensive subjects were categorized into two: non-dipper prehypertensive (NDPH) and dipper prehypertensive (DPH) groups. Serum paraoxonase and arylesterase activities were detected spectrophotometrically.




Results


The groups were comparable in terms of age, gender, body mass index (BMI) and serum glucose, creatinine and lipid parameters, left ventricular (LV) diameters and LV ejection fraction. However, left atrial (LA) diameter, interventricular septum and posterior wall thicknesses, and LV mass index (LVMI) were significantly higher in the NDPH than DPH and controls (p<0.001, p<0.001, p=0.001, and p=0.006, respectively). The measurements of ABPM and paraoxanase and arylesterase activites were shown in Table 1. Paraoxonase and arylesterase activities were significantly lower in patients with NDPH compared to both DPH and control groups. Paraoxonase activity was positively correlated with HDL, and negatively correlated with systolic BP, diastolic BP and LVMI (r1=0.513, r2=-0.460, r3=-0.423, r4=-0.213; and p1,2,3<0.001, p4=0.044, respectively). Arylesterase activity was also positively correlated with HDL, and negatively correlated with systolic BP, diastolic BP and LVMI (r1=0.513, r2=-0.394, r3=-0.361, r4=-0.257; and p1,2,3<0.001, p4=0.015, respectively).




Conclusions


We have demonstrated that NDPH subjects have lower paraoxonase and arylesterase activities compared to DPH subjects and normotensives. Further prospective large scale studies are needed to clarify the role of paraoxonase and arylesterase activities in the development of HT in prehypertensive subject s.




Figure


Paraoxonase and arylesterase activities of prehypertensive and control subjects. Pre-HT stands for prehypertensive.




Comparison of demographic, biochemical and echocardiographic measurement, and 24-hour ambulatory blood pressure monitoring parameters of prehypertensive and control groups














































































































































































































































Control
n=30 		DPH
n=28 		NDPH
n=32 		p* p1 p2 p3
Age, years 39.7 ± 7.3 39.5 ± 6.3 40.9 ± 4.4 0.251
Female Gender, n (%) 19 (37%) 18 (35%) 15 (29%) 0.297
BMI, kg/m2 25.1 ± 1.7 25.6 ± 2.8 25.8 ± 2.9 0.337
Glucose, mg/dL 87.3 ± 10.5 91.8 ± 6.3 89.8 ± 8.7 0.243
Urea, mg/dL 28.5 ± 5.9 28.2 ± 3.1 30.0 ± 6.3 0.397
Creatinine, mg/dL 0.67 ± 0.08 0.70 ± 0.08 0.72 ± 0.12 0.173
Total cholosterol, mg/dL 187 ± 22 193 ± 31 192 ± 33 0.822
HDL cholosterol, mg/dL 47.2 ± 8.9 51.0 ± 10.5 46.4 ± 8.8 0.147
LDL cholosterol, mg/dL 111 ± 22 114 ± 28 112 ± 27 0.854
Triglyceride, mg/dL 135 ± 46 130 ± 58 134 ± 46 0.934#
LVED diameter, mm 47.1 ± 3.5 47.5 ± 2.9 47.8 ± 2.3 0.931
LVES diameter, mm 29.2 ± 3.3 29.2 ± 2.0 29.0 ± 2.0 0.438
IVS#, mm 9.0 (8.7-9.5) 9.5 (9.5-1.0) 10.5 (1.0-1.15) <0.001# <0.001 <0.001 0.001
PW#, mm 8.8 (8.4-9.0) 9.0 (9.0-9.5) 10.0 (9.5-10.5) <0.001# <0.001 <0.001 0.001
LA diameter, mm 30.7 ± 2.2 32.9 ± 2.5 35.3 ± 2.5 <0.001 <0.001 0.001 0.004
LVMI, g/m2 92.1 ± 15.7 97.1 ± 15.6 108.8 ± 19.8 0.001 0.001 0.027 0.531
LVEF, % 67.8 ± 5.1 68.5 ± 2.5 69.3 ± 4.0 0.299
Mean 24-hour SBP, mmHg 108.9 ± 5.0 122.3 ± 8.7 125.5 ± 5.1 <0.001 <0.001 0.143 <0.001
Mean 24-hour DBP, mmHg 71.1 ± 5.5 79.8 ± 6.2 80.8 ± 2.6 <0.001 <0.001 0.686 <0.001
Mean Daytime SBP, mmHg 114.4 ± 4.0 130.6 ± 6.5 131.1 ± 6.2 <0.001 <0.001 0.932 <0.001
Mean Daytime DBP, mmHg 75. 4 ± 4.3 85.8 ± 5.2 84.4 ± 2.5 <0.001 <0.001 0.415 <0.001
Mean Nighttime SBP, mmHg 102.6 ± 7.3 110.3 ± 9.8 120.8 ± 6.3 <0.001 <0.001 <0.001 0.001
Mean Nighttime DBP, mmHg 67.1 ± 5.9 72.3 ± 6.5 78.5 ± 2.6 <0.001 <0.001 <0.001 0.001
Paraoxanase activity, U/L 120.1 ± 39.2 100.3 ± 22.5 82.0 ± 21.5 <0.001 <0.001 <0.001 <0.001
Arylesterase activity, U/L 254.4 ± 30.4 224.1 ± 23.7 193.1 ± 29.8 <0.001 <0.001 <0.001 <0.001

Only gold members can continue reading. Log In or Register to continue

Related posts:

  1. OP-001 An Under-estimated Complication ff Atrial Fibrillation Ablation: Gastroparesis
  2. OP-038 Reduction of Eosinophil Percentage may Predict the Mortality from Acute Coronary Syndromes
  3. OP-065 Increased Platelet-to-Lymphocyte Ratio is Related to Slow Coronary Flow
  4. OP-100 Pulmonary Function after Transcatheter Aortic Valve Implantation in Patients with High Risk Aortic Stenosis

Stay updated, free articles. Join our Telegram channel
Tags:
Nov 30, 2016 | Posted by in CARDIOLOGY | Comments Off on PP-089 Paraoxonase and Arylesterase Activities in Dipper and Non-dipper Prehypertensive Subjects

Full access? Get Clinical Tree
Get Clinical Tree app for offline access