Introduction
There is still uncertainty about the pathophysiological role of Magnesium in the course of acute coronary syndrome. Since Magnesium is considered to be natural physiologic ‘Calcium antagonist’, the balance between Calcium and Magnesium seems to be more important to reflect its homoeostasis rather than the measurement of serum Magnesium level.
Material-Methods
A total of 92 patients (67 male, mean age 61.19 ± 13.64 years) with the diagnosis of acute coronary syndrome were enrolled into this study. Patients were divided into 2 groups by non–ST-segment elevation myocardial infarction to ST-segment elevation myocardial infarction. Clinical and demographic characteristics, and the results of blood samples within 24 hour of admission were evaluated.
Material-Methods
A total of 92 patients (67 male, mean age 61.19 ± 13.64 years) with the diagnosis of acute coronary syndrome were enrolled into this study. Patients were divided into 2 groups by non–ST-segment elevation myocardial infarction to ST-segment elevation myocardial infarction. Clinical and demographic characteristics, and the results of blood samples within 24 hour of admission were evaluated.
Results
The mean Calcium to Magnesium ratio for the entire subject cohort on admission was 4.28 ± 0.53. Although serum Calcium level was not statistically significantly different between two groups, the patients with ST-segment elevation myocardial infarction were found to have significantly low levels of serum Mg as compared to the non–ST-segment elevation myocardial infarction group (p = 0.004). Consistently, ST-segment elevation myocardial infarction was associated with higher Calcium to Magnesium ratio as compared those with non–ST-segment elevation myocardial infarction. In multivariate linear regression analysis, acute coronary syndrome presentation (ST-segment elevation myocardial infarction or non–ST-segment elevation myocardial infarction) (Adjusted OR = 0.262; 95%CI= 0.048 – 0.476; p= 0.017) and serum triglyceride (Adjusted OR = -0.002; 95%CI= -0.001 – 0.000; p= 0.027) were found as independent predictors of serum Calcium to Magnesium ratio.
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