Background
Primary percutaneous coronary intervention (PPCI) is the preferred therapy for ST elevation myocardial infarction (STEMI). The first aim during PPCI is providing a TIMI III flow in culprit vessel. Morever, a good myocardial tissue perfusion is of great importance to prevent for short and long term adverse cardiac events. Platelets play a key role in the pathogenesis of cardiovascular diseases. The activated platelets release several substances acting as mediators of thrombogenesis as well as inflammation. As a morphological parameter of platelets, mean platelet volume (MPV) is widely studied in a variety of cardiovascular disorders. However, there is a few data regarding the role of the platelet distribution width (PDW) in these circumstances.
Methods
In this cross sectional single-center study, 74 patients (58 males, 16 females, age 61.2 ± 12.9 years) who underwent successful PPCI (defined as TIMI III flow in culprit vessel) in the setting of STEMI were evaluated. Myocardial blush grade (MBG) was quantified using the method of Van’t Hoff. Impaired myocardial perfusion was accepted as a MBG score of 0 or 1, and normal / better myocardial perfusion a MBG score of 2 or 3 in corresponding coronary territories after PCI. Venous blood samples were drawn at the emergency department or the coronary care unit before angiography. Echocardiographic left ventricular ejection fraction was calculated within 12 hours after PCI.
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