Aims
Contrast-induced nephropathy is one of the most common cause of hospital-acquired acute renal failure. Oxidative stress and vasoconstriction might play key roles in its pathogenesis. In a few experimental models, antioxidant properties of carvedilol have been documented. The aim of this study was to analyze and compare the effects of carvedilol and metoprolol on development of contrast-induced nephropathy in patients undergoing coronary angiography.
Methods
One-hundred patients currently taking metoprolol and 100 patients currently taking carvedilol were enrolled into the study. Venous blood samples were obtained before and 48 hours after contrast administration. Cystatin C and malondialdehyde values were examined and compared. Contrast-induced nephropathy was defined as a creatinine increase of at least 25% or 0.5 mg/dl from baseline value.,
Methods
One-hundred patients currently taking metoprolol and 100 patients currently taking carvedilol were enrolled into the study. Venous blood samples were obtained before and 48 hours after contrast administration. Cystatin C and malondialdehyde values were examined and compared. Contrast-induced nephropathy was defined as a creatinine increase of at least 25% or 0.5 mg/dl from baseline value.,
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