Objectives
Thiols constitute the intracellular oxidant defense mechanism. It is known that the thiol/disulphide homeostasis is related to atherosclerotic diseases. But, there no data in literature whether is there a relationship between critical coronary artery diseases and thiol/disulphide homeostasis. The study aims to evaluate plasma thiol-disulfide homeostasis the patients with and without significant epicardial coronary artery stenosis.
Methods
Fourty patients with significant coronary artery stenosis (SCAS), 30 patients without SCAS, 40 patients with normal coronary (NC) and 40 healthy volunteers were included to the study population. Plasma thiols (SH) and disulfide (SHHS) levels were measured by a novel and automated spectrophotometric method. The thiol-disulfide homeostasis was calculated as SH/SHHS ratio.
Methods
Fourty patients with significant coronary artery stenosis (SCAS), 30 patients without SCAS, 40 patients with normal coronary (NC) and 40 healthy volunteers were included to the study population. Plasma thiols (SH) and disulfide (SHHS) levels were measured by a novel and automated spectrophotometric method. The thiol-disulfide homeostasis was calculated as SH/SHHS ratio.
Results
Plasma SH and SHHS levels were lowest in patients with SCAS and were highest in control group. Total SH was also different among in the groups (Table-1). However, SH/SHHS ratio was similar between the groups (p=0.405). Plasma SH and SHHS levels were similar between patients with NC and without SCAS but SH was only significant different between with and without SCAS group (Figure-1A and 1B). ROC- curve analysis revealed that thiol levels over 250 μmol/L predicted SCAS with 77% sensitivity and 72% specificity (area under the curve=0.795; 95% CI 0.718-0.873).
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