Objectives

The oxidative stress plays crucial role in the progression of atherosclerosis. It was known that increased oxidative stress and impaired antioxidant protection are more associated with acute coronary syndromes (ACS) than stable angina. The plasma thiol (SH) is water-soluble and cytoplasmic antioxidant protection molecules. It is exclusively associated with the sulfur-containing tripeptide glutathione (γ-glutamyl-cysteinyl-glycine). A review of the literature demonstrates that the dynamix thiol-disulfide homeostasis has not discussed in acute coronary syndrome. The study aims to investigate the dynamic thiol-disulfide homeostasis in acute coronary syndromes.

Methods

The study population contained 133 patients with ACS, 38 patients with stable angina (SA) and 47 voluntary healthy subjects. Plasma SH and disulfide (SHHS) levels were measured by a novel and automated spectrophotometric method. The thiol-disulfide homeostasis was calculated as SH/SHHS ratio.

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