Coronary artery disease ((CAD) and the results obtained regarding the relationship between androgen hormone levels are contradictory and controversial. In our study, we aimed to determine the possible effects of androgen hormones (DHEA-S, free testosterone (FT), total testosterone (TT)) levels over CAD and its degrees, and to evaluate the relationship between androgen hormones and risk factors for CAD and left ventricular ejection fraction (LVEF). 201 male patients got the diagnosis of coronary artery disease by coronary angiography and 51 intact male subjects identified as individuals with normal coronary anatomy by coronary angiography as a control group were enrolled in the study. The mean age of 55.5± 8.5 and 49.7±6.7 years, mean body mass index (BMI) of 26.5±2.3 and 26.10±2,4 kg/m ² were found in the study for patients and robust group respectively. Ther was not statistically significant difference between the two groups for every aspect of the age and BMI.

Smoking rates between the patient and control groups were as 107 (53.2%) and 18 (35.3%) respectively (p=0.007). The frequency of the hypertension (HT) was noted as of 93 (46.3%) and 7 (13.7%) (p=0.011), diabetes mellitus (DM) of 78 (38.8%) and 3 (5.9%) (p=0.010) and the frequency of hyperlipidemia (HL) of 104 (51.7%) and 13 (25.5%) (p=0.004). Left ventricular ejection fraction (LVEF) was 52%±7.7 and 64%±3.5 (p<0.001) in patients and controls, respectively.

When the study group of patients with CAD and non-CAD control group of laboratory test results are evaluated, total testosterone (ng/dL) 246.5±89.3 and 260±111.7, p=0.042; free testosterone (pg/ml) 8.3±2.7 and 13.27±5.18, p=0.016; DHEA-S (μg/dL) 88.4±33 and 229.19±62, p=0.007 were determined respectively; and differences between both groups were observed statistically significant. Risk factors of the HT and HL was not observed statistically significant (p = 0.302). There was found a positive relationship between the presence of DM or HT and CAD, and statistically significant difference was observed (p=0.006). When the relationship between DHEA-S and LVEF was evaluated, LVEF was lower in patients with low DHEA-S which showed a statistically significant difference (p=0.001). When the correlation of DHEA-S levels and CAD was compared, there was no relationship between the number of vessels and DHEA-S, the difference was not statistically significant (p≥0,05).

In conclusion, in addition to confirm the statistically significant relationship between CAD and DM, HL, HT, LVEF in our study, androgen hormone (DHEA-S, FT, TT) levels in patients with CAD were determined to be statistically significantly lower.