OP-93 Ischemic Events after PCI in Stable Coronary Artery Disease According to Platelet Reactivity and Genetic Testing




Objective


We aimed to evaluate the risk factors of ischemic events in patients with stable CAD in the preoperative and postoperative period during percutaneous coronary intervention according to laboratory data and CYP2C19 genetic polymorphism.




Methods


A total of 55 consecutive patients undergoing PCI were prospectively enrolled (age 59±9,68 yo). Mean follow-up period was 20 (± 7,85) months. All patients received a loading dose of clopidogrel 600 mg and aspirin 325 mg, before PCI, and maintaining doses (75 mg clopidogrel and 100 mg aspirin) there after. Assessment of platelet reactivity in the perioperative period was performed using light transmission aggregometry with 5 mmol/L ADP (LTA-ADP), VerifyNow and Thromboelastography with «PlateletMapping» kit. Evaluation of reactivity in the post-operative period was performed using the LTA-ADP. CYP2C19 genotyping was performed in all patients. Endpoints were: death from cardiovascular causes, acute myocardial infarction, angina recurrence, repeated endovascular intervention, stent thrombosis.

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Nov 30, 2016 | Posted by in CARDIOLOGY | Comments Off on OP-93 Ischemic Events after PCI in Stable Coronary Artery Disease According to Platelet Reactivity and Genetic Testing

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