Background and Purpose
Epicardial adipose tissue secretes various proatherogenic mediators, and accomodates ganglionic plexi which may affect autonomic nervous system function. Epicardial adipose tissue thickness (EATT) is a novel surrogate of cardiovascular risk which is associated with the presence and severity of coronary artery disease (CAD). Increased EATT independently predicts major adverse cardiovascular events. Decreased heart rate variability (HRV) denotes high risk of cardiovascular events, including sudden cardiac death. We aimed to investigate the relationship between EATT and HRV.
Methods
Ninety-eight patients were included in the study. Patients with documented CAD, atrial fibrillation or any sustained significant arrhythmia, and obese subjects (BMI≥30) were excluded. EATT was determined using transthoracic echocardiography. HRV was assessed using the SDNN value (standard deviation of the intervals between normal beats, in milliseconds) which was obtained from the analysis of 24-hour Holter ECG monitoring. Impaired HRV was defined as SDNN < 100 msec. The correlation between EATT and SDNN was statistically analyzed and necessary adjustments were made. ROC curve analysis was also performed.
Methods
Ninety-eight patients were included in the study. Patients with documented CAD, atrial fibrillation or any sustained significant arrhythmia, and obese subjects (BMI≥30) were excluded. EATT was determined using transthoracic echocardiography. HRV was assessed using the SDNN value (standard deviation of the intervals between normal beats, in milliseconds) which was obtained from the analysis of 24-hour Holter ECG monitoring. Impaired HRV was defined as SDNN < 100 msec. The correlation between EATT and SDNN was statistically analyzed and necessary adjustments were made. ROC curve analysis was also performed.
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