Background
The advances in the biochemical research for the discovering an ideal biomarker for the diagnosis of acute myocardial infarction have led to discovery of cardiac troponins as a gold standard marker of myocardial injury. By courtesy of advances in the immunoassay techniques, the 99th percentile cutoff value of cardiac troponins required for the diagnosis of acute myocardial infarction decreased, with the latest available ultrasensitive cardiac troponin assays capable of measuring level as low as 0.005 ng/ml. Troponins have both diagnostic as well as prognostic significance in myocardial necrosis, but the results must be interpreted nin the context of clinical history, ECG findings, and cardiac imaging techniques like echocardiography to establish the correct diagnosis.
Purpose
Cardiac troponins are also elevated in other cardiac conditions such as cardiomyopathy, heart failure, renal failure, pulmonary embolism, etc. the serial monitoring of the cardiac troponins along with the absolute value would help to differentiate myocardial infarction from these many other conditions. In this study, we aimed to investigate the positive predictive value of four different cardiac troponin assays in the diagnosis of acute myocardial infarction.
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