Background

Genetic predisposition is an important risk factor for coronary artery disease. Genetic studies showed that single nucleotide polymorphisms on chromosome 9p21 are related to coronary atherosclerosis and myocardial infraction in different populations. In this study we aimed to evaluate the impact of polymorphisms on chromosome 9p21 on presence and severity of CAD in Turkish population.

Method

We prospectively included 646 patients undergoing coronary angiography on an outpatient basis. The number of the coronary arteries with >%50 stenosis (coronary vessel score), and Gensini score were calculated to assess the angiographic severity of CAD. Alleles of AA, AG and GG were determined for rs10757274 and rs2383206 polymorphisms located on chromosome 9p21 from the blood samples taken before coronary angiography.

Method

We prospectively included 646 patients undergoing coronary angiography on an outpatient basis. The number of the coronary arteries with >%50 stenosis (coronary vessel score), and Gensini score were calculated to assess the angiographic severity of CAD. Alleles of AA, AG and GG were determined for rs10757274 and rs2383206 polymorphisms located on chromosome 9p21 from the blood samples taken before coronary angiography.

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