Objectives
It has been demonstrated in animal studies that increased oxidative stress negatively affects left ventricular diastolic function. But there is no sufficient data about relation between the oxidative stress and left ventricular diastolic dysfunction (LVDD) in patients with stable angina. The main objective of this study was to investigate the impact of oxidative stress on LVDD in patients with stable angina.
Material and Methods
This study included 42 patients with stable angina and normal left ventricular ejection fraction. The cases were classified as group I (n = 21, 12 males, mean age 55 ± 12 years) with LVDD (with phase I diastolic function (impaired relaxation), and group II (n = 21, 13 males, mean age 45 ± 11 years) without LVDD. The total antioxidant capacity (TAC) and the total oxidant level (TOS) were measured by automatic method. Oxidative stress index (OSI) was calculated via TAC and TOS.
Material and Methods
This study included 42 patients with stable angina and normal left ventricular ejection fraction. The cases were classified as group I (n = 21, 12 males, mean age 55 ± 12 years) with LVDD (with phase I diastolic function (impaired relaxation), and group II (n = 21, 13 males, mean age 45 ± 11 years) without LVDD. The total antioxidant capacity (TAC) and the total oxidant level (TOS) were measured by automatic method. Oxidative stress index (OSI) was calculated via TAC and TOS.
Results
Clinical, echocardiographic and oxidative parameters are also shown in table 1. Gender, body mass index, taken medicine, blood pressure, lipid levels, blood glucose, heart rate, ejection fraction, TAC, OSI, and isovolumic relaxation time were found to be similar between the groups (all of p> 0.05). Although age, TOS, peak A, and lateral A velocity values were higher, peak E, peak E/ peak A ratio, deceleration time, and lateral E velocity were lower in group I than II (all of p< 0.05). A significant correlation was found between presence of the LVDD and age, TOS, OSI, high density lipoprotein-cholesterol (All of p<0.05). However, multivariate analysis demonstrated that LVDD is independently associated with age (β=-0.607, p<0.001).
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