OP-056 Plasma Thiol-Disulfide Homeostasis in Patients with Cardiac Syndrome X




Objectives


The cardiac syndrome X (CSX) is characterized by microvascular dysfunction which associated with oxidative stress. Thiols are mainly responsible for the intracellular antioxidant status. They are sulfur analogs of alcohols and found as frees (thiols=SH) and oxidized from (disulfide=RSSH) in plasma. This study was conducted to investigate whether there is dynamic thiol-disulfide homeostasis in patients with CSX.




Methods


Forty-eight patients with CSX, 40 age-gender matched controls were included in the study. Plasma thiols (SH) and disulfide (SHHS) levels were measured by a novel and automated spectrophotometric method. The thiol-disulfide homeostasis was calculated as SH/SHHS ratio.

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Nov 30, 2016 | Posted by in CARDIOLOGY | Comments Off on OP-056 Plasma Thiol-Disulfide Homeostasis in Patients with Cardiac Syndrome X

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