Introduction
Metabolic syndrome (MS) is cluster of risk factors associated with development of Type 2 Diabetes Mellitus and cardiovascular disease. Using different diagnostic criteria may define different MS prevalence even in the same population. Using the appropriate diagnostic criteria in proper group of patients may be helpful in management of these risk factors. Reduction of aortic distensibility (AD) is associated with subclinical generalized atherosclerosis. Multiparity was shown to be associated with increased waist circumference which is an important criterion in MS diagnosis. In this context, here we aimed to compare two most commonly used diagnostic criteria for MS (revised Adult Treatment Panel III and International Diabetes Federation criteria) by means of evaluating possible association of AD as a marker of atherosclerosis with MS diagnosed according to these criteria in postmenopausal grand multiparous women.
Methods
Fifty-seven consecutive, postmenopausal, grand multiparous (five or more births mean 9±2.4) female patients without known coronary artery disease between ages 45-75 (mean 57.8±7) were enrolled to the study. Diagnosis of MS was done according to revised ATP III and IDF criteria, separately. Blood pressure, pulse pressure, waist circumference, and levels of total cholesterol, HDL and LDL cholesterol, triglyceride, number of birth were noted. Systolic and diastolic diameters of the ascending aorta were measured by M-mode echocardiography from the parasternal long-axis views, and AD were calculated. Possible association of AD with MS diagnosed according to different diagnostic criteria was evaluated.
Methods
Fifty-seven consecutive, postmenopausal, grand multiparous (five or more births mean 9±2.4) female patients without known coronary artery disease between ages 45-75 (mean 57.8±7) were enrolled to the study. Diagnosis of MS was done according to revised ATP III and IDF criteria, separately. Blood pressure, pulse pressure, waist circumference, and levels of total cholesterol, HDL and LDL cholesterol, triglyceride, number of birth were noted. Systolic and diastolic diameters of the ascending aorta were measured by M-mode echocardiography from the parasternal long-axis views, and AD were calculated. Possible association of AD with MS diagnosed according to different diagnostic criteria was evaluated.
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