Objective
Neutrophil to lymphocyte ratio is a novel parameter for cardiovascular research area. The higher values of neutrophil to lymphocyte ratio have been found to be associated with worse clinical outcomes in aterosclerotic heart disease, heart failure, heart valve disease and other various cardiovascular disorders. Nevertheless the association between neutrophil to lymphocyte ratio and diastolic dysfunction has not been propounded as yet. We herein eveluated the association beteween neutrophil to lymphocyte ratio and diastolic dysfunction.
Methods
The study population consisted of 41 hypertensive patients with any grade of diastolic dysfunction. Forty one hypertensive patients without diastolic dysfunction determined by echocardiographic evaluation constituted the control group. All of the hypertensive patients in both study and control groups were new diagnosed or aware of the disease without use of any pharmacotherapy.
Methods
The study population consisted of 41 hypertensive patients with any grade of diastolic dysfunction. Forty one hypertensive patients without diastolic dysfunction determined by echocardiographic evaluation constituted the control group. All of the hypertensive patients in both study and control groups were new diagnosed or aware of the disease without use of any pharmacotherapy.
Results
Baseline characteristics and parameters that are thought to be associated with neutrophil to lymphocyte ratio were compared and the results are given in Table 1. Body mass index, systolic blood pressure, heart rate, serum high density lipoprotein (HDL), triglyceride levels and sedimentation rates differ significantly between two groups (P<0.05). Nevertheless multiple regression analysis revealed that none of these parameters have a significant impact on neutrophil to lymphocyte ratio. Besides, there was no statistically significant difference between two groups by the means of body surface area, diastolic blood pressure, serum low density lipoprotein concentration and fibrinojen and C- reactive protein (CRP) levels (p>0.05). Mean neutrophil to lymphocyte ratio value was found to be 2,07±0,82 in the study group while the control group had a mean value of 1,69±0,60 (p=0,020). The patients with diastolic dysfunction had significantly higher values of neutrophil to lymphocyte ratio. When grades of diastolic dysfunction were compared, neutrophil to lymphocyte ratio was 1,80±0,82, 2,32±0,73 and 2,75±0,45 in patients with grade 1, grade 2 and grade 3 diastolic dysfunction respectively and the difference was statistically significant (p=0,001). None of the other hematologic parameters differ significantly in patients with diastolic dysfunction when compared to controls.
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