Effect of endovascular and open abdominal aortic aneurysm repair on thrombin generation and fibrinolysis

Abdelhamid MF, Davies RSM, Vohra RK, et al (Solihull Hosp, Birmingham, UK; Univ Hosp, Birmingham NHS Foundation Trust, UK) J Vasc Surg 57:103-107, 2013^§

Abstract

Background

Abdominal aortic aneurysm (AAA) is associated with a prothrombotic diathesis that may increase the risk of cardiovascular events. This diathesis is exacerbated in the short term by open aneurysm repair (OAR) and endovascular aneurysm repair (EVAR). However, the effect of EVAR and OAR on coagulation and fibrinolysis in the medium and long term is poorly understood. The purpose of this study was to investigate the medium-term effects of EVAR and OAR on thrombin generation, neutralization, and fibrinolysis.

Methods

Prothrombin fragment (PF)1 + 2, thrombin antithrombin (TAT) complex, plasminogen activator inhibitor (PAI) activity, and tissue-plasminogen activator (t-PA) antigen were measured in eight age-matched controls (AMCs), 29 patients with AAA immediately before (preoperatively) and 12 months after EVAR (post-EVAR), and in 11 patients at a mean of 16 months after OAR (post-OAR).

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