Occlusive Disease: Endovascular Management

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© Springer Science+Business Media, LLC, part of Springer Nature 2021
J. J. Hoballah, C. F. Bechara (eds.)Vascular Reconstructionshttps://doi.org/10.1007/978-1-0716-1089-3_26


26. Aortoiliac Occlusive Disease: Endovascular Management



Justin R. King1, John G. Maijub1 and Raghu L. Motaganahalli1  


(1)
Department of Surgery, Division of Vascular Surgery, Indiana University School of Medicine, Indianapolis, IN, USA

 



 

Raghu L. Motaganahalli



Keywords
Aortoiliac occlusive diseaseAIODClaudicationCritical limb ischemiaLeriche syndromeIliac artery stentingAortofemoral stentingHybrid procedures


Aortoiliac occlusive disease (AIOD) is a form of peripheral artery disease (PAD) characterized by the development of atherosclerotic plaques specifically within the abdominal aorta and iliac arteries. The disease process is progressive in nature, and patients may range from asymptomatic individuals to those with critical limb ischemia in the form of rest pain or tissue loss. Patients may also present with Leriche syndrome, with buttock claudication and erectile dysfunction due to poor perfusion of the internal iliac arteries. The diagnosis of AIOD is often considered following abnormal lower extremity arterial doppler studies, and ultimately is confirmed by contrast-enhanced cross-sectional imaging or fluoroscopic angiography. Early risk factor reduction and medical management has a role in reducing the progression of disease in all patients, but endovascular and open surgical intervention may be required for those with critical limb ischemia or symptoms that are severely limiting.


Risk Factor Reduction and Medical Management


As with other forms of atherosclerotic disease, risk factor modification is critical in stabilizing the disease process to prevent limb loss or associated cardiovascular mortality and morbidity. In patients who have no significant limitations of the quality of life, noninterventional treatment options of smoking cessation and regimented exercise should be considered, as these have demonstrated the greatest benefit for those with early atherosclerotic changes. Other beneficial steps include adequate control of diabetes mellitus, hypertension, and hyperlipidemia.


Two types of agents in particular have demonstrated the greatest benefit with regards to medical management: antiplatelet and cholesterol-lowering medications. The consensus guidelines of the Society for Vascular Surgery recommend the use of aspirin for all patients with PAD, given its demonstrated reduction in myocardial infarction, stroke, and all-cause mortality [1, 2]. Also recommended are statin medications. The Heart Protection Study Collaborative Group has demonstrated significantly reduced mortality in patients with PAD taking a high-dose statin, so it is recommended unless otherwise contraindicated [3].


Endovascular Repair


Indications


Endovascular repair is considered an attractive treatment option for many patients, and it may be a primary option for those in whom open surgery poses significant risk. Severe disease burden including total occlusion may make endovascular repair technically challenging, however, so it is most commonly reserved for those with significant unilateral or bilateral iliac artery disease burden without the presence of aortic occlusion. But with the evolution of endovascular technology, it is no longer unusual to consider treating even more complex proximal occlusion, including Infrarenal aortic occlusion, with this approach. Benefits of an endovascular approach include reduction in perioperative mortality and the opportunity to treat distal lesions during the same procedure. Although the 2- to 5-year primary patency rates as low as 60% are considerably inferior to the rates for open bypass, assisted primary patency and secondary patency are almost similar to those achieved by open reconstructions, so these percutaneous interventions should be reserved for select patients [47].


Complications of endovascular interventions include those related to access, contrast use, and radiation, as well as the specific complications related to the treatment of the arteries themselves. Major complications such as bleeding, embolization into visceral arteries causing end organ damage, or rupture of the vessel can be devastating.


Any consideration of endovascular therapy for AIOD should address the inflow and outflow disease. It may be advantageous to employ a totally endovascular approach or a hybrid approach using a combination of endovascular and open techniques. The major advantage of endovascular therapy is the limitation of the morbidity and mortality resulting from an open approach. For a hybrid approach, inflow is generally established with an endovascular strategy, whereas the outflow through the femoral arteries may need either a femoral endarterectomy or profundaplasty.


Iliac Artery Stenting


Definitive endovascular management of iliac disease is traditionally accomplished with bilateral iliac stenting, often referred to as “kissing iliac stents.” The stenting is completed via bilateral retrograde common femoral artery (CFA) access and requires 6- to 8-French sheaths. Both balloon-expandable and self-expanding stents have demonstrated technical success, though covered stents demonstrated long-term superiority in the COBEST trial [8]. Normal common iliac artery size ranges from 8 mm to 14.5 mm in males and 8 mm to 10.5 mm in females, so standard iliac stents range from 6 to 10 mm in diameter [9, 10]. Simultaneous expansion of stents is recommended to prevent malalignment and stent occlusion. Extension into the distal aorta is also recommended. Percutaneous transluminal angioplasty (PTA) alone has demonstrated similar rates of technical success, but because of its poor rates of primary and secondary patency (as low as 50% at 4 years), it is no longer recommended [11].


Several configurations for endovascular reconstructions for aortoiliac arteries are shown in Fig. 26.1. The choice depends on the anatomy of the segment that need to be treated.

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Fig. 26.1

Configurations for aorto-iliac reconstructions


Following are steps for an iliac artery angioplasty and stent exclusively addressing the common iliac and external iliac arteries:



  1. 1.


    Obtain ultrasound-guided or fluoroscopic-guided access to the femoral arteries, followed by placement of working access sheaths. Bilateral access is required when addressing stenosis or occlusion at the origin of common iliac arteries.


     


  2. 2.


    Traverse the lesion using a hydrophilic wire, and maintain the wire access in the true lumen.


     


  3. 3.


    Perform adequate intravenous heparinization (100 IU per kg body weight).


     


  4. 4.


    Exchange the wires for stiff wires.


     


  5. 5.


    If the patient has total occlusion, perform predilation with at least a 3- to 4-mm balloon, to help advance the delivery sheaths and placement of stents across the diseased segments. In heavily calcified lesions, it is helpful to advance a sheath through the lesion and place the stent in the sheath in order to protect the stent.


     


  6. 6.

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Jul 25, 2021 | Posted by in CARDIOLOGY | Comments Off on Occlusive Disease: Endovascular Management

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